Mesacol Od Tablet 15’S
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Introduction About MESACOL OD TABLET
Mesacol OD Tablet contains Mesalamine, an anti-inflammatory drug used to manage ulcerative colitis and Crohn’s disease. It helps reduce inflammation in the intestines and provides long-term relief.
Take Mesacol OD once daily after meals as directed by your doctor. Your doctor may decide the correct dose depending on your age, body weight and health condition. For adults and elderly patients, a maximum of 4.8g per day is recommended. Patients with kidney problems and liver problems must take this medicine with caution. Careful monitoring of liver and kidney functions, regular health checkups and dose adjustments are required in such patients.
While taking mesacol OD long-term to prevent remission of disease, it is important to closely follow the health advice suggested by your doctor, undergo regular kidney function tests, and never skip doses, to get better control over flare-ups.
Mesacol OD should be used in pregnant only if considered necessary by the physician. Clinical studies have demonstrated that higher doses of mesalamine can harm the growing baby. Hence, your doctor will decide whether you should take this medicine or not if you are pregnant.
Mesalamine can pass through breast milk and can cause stomach upset in nursing infant. Hence, mesacol OD should be discontinued or used with extreme caution in breastfeeding women.
The most common side effects of taking mesacol OD are nausea, bloating, indigestion, stomach irritation or upset, headache, dizziness or tiredness. Consult your doctor if any of these symptom trouble you.
Seek immediate medical attention, if you experience severe stomah pain with bloody stools, skin reactions, trouble in passing urine or have severe nausea and vomiting with stomach discomfort.
Uses Of MESACOL OD TABLET
It is used in the management of inflammatory bowel diseases such as:
- Ulcerative colitis
- Crohn’s disease
Who Should Take Mesacol OD?
- Patients with mild to moderate ulcerative colitis – Helps reduce inflammation and manage symptoms like diarrhea and rectal bleeding.
- Individuals needing maintenance therapy – Reduces flare-ups and maintains remission in ulcerative colitis.
- People with inflammatory bowel disease (IBD) – Helps control chronic inflammation in the colon.
- Those prescribed by a doctor for long-term bowel health – Supports gut health and prevents disease progression.
- Patients without salicylate allergy or severe kidney/liver disease – Should be used cautiously in individuals with pre-existing conditions.
Benefits of MESACOL OD TABLET
Mesacol OD for ulcerative colitis:
- Reduces inflammation in the colon, relieving symptoms like diarrhea, rectal bleeding, and abdominal pain.
- Promotes healing of the intestinal lining, improving overall gut health and preventing complications.
Mesacol OD for Crohn’s disease:
- Helps control mild to moderate inflammation in the intestines, reducing discomfort and flare-ups.
- Aids in symptom relief, such as diarrhea and abdominal pain, improving quality of life.
Mesacol OD for Maintaining Remission in Ulcerative Colitis:
- Reduces recurrence of symptoms by keeping inflammation under control.
- Supports long-term bowel health, reducing the need for stronger medications or surgery.
How to use MESACOL OD TABLET
Take Mesacol OD exactly as prescribed by your doctor. Consistent daily intake at the same time is recommended to maintain effective drug levels.
How to Take Mesacol OD Tablet:
- Usually, it is taken once daily with food to prevent stomach upset.
- Swallow the tablet whole with water; do not crush or chew it.
- Maintain adequate fluid intake during therapy to support kidney function.
Mesacol OD – Recommended Dosage For Adults:
- Induction of Remission: For active, mild to moderate ulcerative colitis, the typical dosage is 2.4g to 4.8g taken once daily. Clinical studies have shown that doses up to 4.8g per day are effective in inducing remission.
- Maintenance of Remission: To maintain remission, a lower dose as prescribed by your doctor may be sufficient.
Mesacol OD Dosage for Children:
The safety and effectiveness of Mesacol OD in pediatric patients have not been established. Use in children should only occur if prescribed by a qualified healthcare professional, with dosage adjustments based on the child’s weight and clinical condition.
Mesacol OD Dose Adjustments for Liver and Kidney Patients:
- Kidney Impairment: Mesalamine is known to be substantially excreted by the kidneys. Patients with impaired renal function should use Mesacol OD with caution, and renal function should be evaluated prior to and during therapy.
- LiverImpairment: Caution is advised when administering Mesacol OD to patients with liver disease. Monitoring liver function tests may be necessary.
Mesacol OD Maximum Daily Dosage?
The maximum recommended daily dose for adults is 4.8g. Exceeding this dose may increase the risk of adverse effects and is not advised unless under strict medical supervision.
Can I stop taking Mesacol OD suddenly?
Do not abruptly discontinue Mesacol OD without consulting your doctor, as sudden cessation may lead to a relapse of symptoms. If discontinuation is necessary, your doctor will provide a tapering schedule appropriate for your condition.
What to Expect After Taking Mesacol OD?
- Symptom Improvement: Patients may notice a reduction in symptoms such as diarrhea, rectal bleeding, and abdominal pain within a few weeks of starting therapy.
- Maintenance of Remission: Continued use as prescribed helps maintain remission and prevent flare-ups of ulcerative colitis.
What if I forgot to take MESACOL OD TABLET
If you miss a dose, take it as soon as you remember. If it’s near the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once to make up for a missed dose.
Overdose
- Symptoms: Overdose may lead to symptoms such as nausea, vomiting, stomach pain, dizziness, or, in severe cases, renal impairment.
- Action: In case of suspected overdose, seek immediate medical attention. Supportive measures and symptomatic treatment should be initiated promptly.
Side Effects Of MESACOL OD TABLET
Like all medicine, Mesacol OD may cause certain side effects in some individuals, although not everybody gets them,
Common Side Effects of Mesacol OD are:
- Nausea
- Headache
- Diarrhea
- Abdominal pain, indigestion
- Sleepiness or Dizziness
- Tiredness, Fatigue
Can Mesacol OD Cause Kidney Problems?
- Yes, Mesacol OD (mesalamine) may cause kidney problems, including interstitial nephritis (kidney inflammation), which can lead to reduced kidney function over time.
- Patients with pre-existing renal impairment should use Mesacol OD with caution, and regular kidney function tests (serum creatinine levels) are recommended during therapy.
Does Mesacol OD Affect Liver Function?
- In rare cases, Mesacol OD can cause elevated liver enzymes, indicating potential liver irritation or damage.
- Patients with liver disease should use this medication cautiously and undergo regular liver function tests to monitor any adverse effects.
Is Mesacol OD Safe for Long-Term Use?
- Yes, Mesacol OD is commonly used for long-term maintenance therapy in ulcerative colitis to prevent flare-ups and maintain remission.
- However, long-term use requires regular kidney and liver function monitoring to detect any potential side effects early.
Can Mesacol OD Cause Hair Loss?
- Hair loss (alopecia) has been reported in some patients taking Mesacol OD, though it is a rare side effect.
- This side effect is usually temporary and may improve after stopping or adjusting the medication.
Does Mesacol OD Affect Fertility?
- There is limited evidence suggesting that Mesacol OD significantly affects male or female fertility.
- Some studies indicate that mesalamine may reduce sperm motility in men, but this effect is usually reversible after discontinuation.
Can Mesacol OD Cause Joint Pain or Muscle Pain?
- Yes, joint pain (arthralgia) and muscle pain (myalgia) have been reported as side effects of Mesacol OD.
- These symptoms are typically mild but may require medical attention if persistent or severe.
How Long Do Mesacol OD Side Effects Last?
- Mild side effects (e.g., nausea, headache, stomach discomfort) usually resolve within a few days to weeks as the body adjusts to the medication.
- Serious side effects (e.g., kidney or liver issues) may persist and require discontinuation or medical intervention.
- If side effects do not subside or worsen, consult your doctor for alternative treatment options.
When To Seek Medical Attention?
Stop taking Mesacol OD tablet and consult your doctor immediately in case if you experience:
- serious skin reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis associated with symptoms such as reddish non-elevated, target-like/circular patches on the trunk associated with central blisters, skin peeling, ulcers of eyes, nose, mouth, throat, and/or genitals.
- signs of acute intolerance syndrome such as cramping, severe stomach pain, bloody & excessive stools (diarrhoea), fever, headache, and/or rash.
- unexplained bruising (without injury), rash, anaemia, fever, sore throat, and/or unusual bleeding
- signs of allergic reaction such as swelling of tongue, lips/eyes
- signs of increased pressure in brain such as headache, blurred/dimmed vision, double vision, brief/permanent vision loss, dizziness, nausea, vomiting, and/or ringing in ears
Warning & Precautions
Pregnancy
Consult your doctor
Pregnant women should use Mesacol OD only if prescribed by a doctor, with regular monitoring. Studies have not shown significant birth defects, but high doses may increase the risk of complications such as preterm birth. Therefore, mesacol OD should be used in pregnant women only if the benefits overweigh the risks.
Breastfeeding
Consult your doctor
Studies have shown that mesalamine passes into breast milk, but the amount is usually low. Some breastfed infants have experienced diarrhea or irritability, so monitoring the baby’s reaction is essential. If adverse effects occur in the infant, consult your doctor about alternative treatments or adjusting the dose.
Driving and Using Machines
Use with Caution
Mesacol OD may cause dizziness and sleepiness in some individuals. Therefore, do not drive or perform tasks that require complete alterness.
Alcohol
Consult your doctor
- Avoid or limit alcohol while taking Mesacol OD, as it may increase the risk of stomach irritation and liver toxicity.
- Alcohol can also worsen side effects like nausea, dizziness, and dehydration.
- Chronic alcohol use may strain kidney and liver function, which are already monitored during Mesacol OD treatment.
- If you consume alcohol, consult your doctor to assess potential risks based on your condition.
Kidney
Consult your doctor
Avoid Mesacol OD if you have severe kidney disease. It should be used with extreme caution in patients with mild to moderate kidney problems. Kidney disease patients must periodically check their kidney function as suggested by their doctor to protect from unpleasant side effects. Dose adjustments and careful monitoring are required in such patients
Liver
Consult your doctor
Mesacol OD Tablet is not recommended for use in patients with severe liver problems. It should be used with caution in patients who have/had mild to moderate liver disease. Therefore, inform your doctor before taking mesacol OD, if you have any pre-existing liver conditions so that your doctor can adjust the dose and carefully monitor your health during the therapy duration.
Allergy
Contraindicated
Do not take Mesacol OD Tablet if you are allergic to Mesalamine, salicylates, sulfasalazine, and/or any other ingredients of this medicine.
Lungs
Use with Caution
Mesacol OD Tablet should be used with caution in patients with lung problems. Therefore, inform your doctor before taking mesacol OD if you have lung problems as a precaution.
Heart Disease
Use with Caution
Mesacol OD Tablet should be used with caution in patients with heart problems such as inflammation of heart (due to infection). Consult your doctor before taking Mesacol OD Tablet.
Use In Pediatrics
Contraindicated
Mesacol OD Tablet is not recommended for use in children and adolescents (aged below 18 years) due to lack of data on safety and efficacy of the medicine. Consult your doctor before administering the medicine to the child.
Use In Geriatrics
Use with Caution
Mesacol OD Tablet should be used with caution in elderly patients (aged above 65 years) especially in patients with kidney or liver problems and when consumed in long-term.
Other Warnings for MESACOL OD TABLET
Before taking Mesacol OD Tablet inform your doctor if you:
- have narrowing/blockage of stomach/gut
Safety Advice
Expert Tips To Follow While Taking Mesacol OD:
- Taking Mesacol OD with meals helps improve absorption and reduces stomach discomfort.
- Drink plenty of water to prevent kidney-related side effects and maintain overall hydration.
- Regular kidney (serum creatinine) and liver function tests are recommended during long-term use.
- Alcohol can worsen stomach irritation and liver toxicity, so it’s best to avoid or limit consumption.
- Stopping Mesacol OD suddenly may cause a relapse of ulcerative colitis symptoms. Always consult your doctor before discontinuing.
- Inform your doctor if you are pregnant or breastfeeding, as dosage adjustments may be needed.
- Avoid taking iron supplements or antacids at the same time as Mesacol OD to prevent absorption issues. Maintain a 2-hour gap if necessary.
- Seek medical advice if you experience severe abdominal pain, blood in stools, yellowing of the skin, or kidney-related symptoms like reduced urine output.
Diet and Lifestyle Advice
|
Foods to Eat |
Foods to Avoid |
|
Low-fiber fruits (bananas, melons) |
High-fiber fruits (raw apples, berries) |
|
Well-cooked vegetables (carrots, pumpkin) |
Raw vegetables, cruciferous veggies (broccoli, cauliflower) |
|
Lean proteins (chicken, fish, tofu) |
Red meat, processed meats |
|
White rice, white bread, oats |
Whole grains (brown rice, whole wheat, quinoa) |
|
Lactose-free dairy, plant-based milk |
Full-fat dairy (milk, cheese, cream) |
|
Healthy fats (olive oil, avocado) |
Fried and greasy foods |
|
Herbal teas, water, electrolyte drinks |
Alcohol, caffeinated drinks, carbonated sodas |
Can I Drink Alcohol While Taking Mesacol OD?
- Alcohol can irritate the digestive tract and worsen inflammation, making ulcerative colitis symptoms worse.
- Combining alcohol with Mesacol OD increases the risk of liver toxicity and gastrointestinal discomfort.
- Smoking may worsen IBD symptoms and reduce the effectiveness of treatment.
- It is best to avoid alcohol and smoking while on Mesacol OD for better disease management.
Mesacol OD & Weight Gain/Loss – Impact on Metabolism
- Mesacol OD does not directly cause weight gain or loss, but changes in diet due to ulcerative colitis can affect weight.
- Possible weight loss:
- Reduced nutrient absorption due to inflammation.
- Appetite loss during flare-ups.
- Possible weight gain:
- Increased appetite during remission.
- Reduced physical activity due to fatigue.
- Maintaining a balanced diet and regular exercise can help manage weight effectively.
Stress Management & Ulcerative Colitis
Meditation & Deep Breathing: Reduces anxiety and promotes relaxation.
Regular Exercise: Low-impact activities like yoga and walking help improve gut health.
Adequate Sleep: Helps the body recover and manage inflammation.
Therapy & Support Groups: Talking to others with IBD can provide emotional support.
Managing stress effectively can help improve overall quality of life and reduce ulcerative colitis flare-ups.
Mesacol OD vs Mesacol 400mg vs. Budez CR
|
Feature |
Mesacol OD |
Mesacol 400mg |
Budez CR |
|
Active Ingredient |
Mesalamine (1.2g) |
Mesalamine (400mg) |
Budesonide (3mg) |
|
Mode of Action |
Anti-inflammatory effect on colon lining |
Anti-inflammatory effect on colon lining |
Suppresses immune response & inflammation |
|
Indication |
Ulcerative colitis (mild to moderate) Crohn’s disease, |
Ulcerative colitis (mild to moderate) Crohn’s disease |
Crohn’s disease, Ulcerative colitis (moderate to severe) |
|
Release Mechanism |
Extended-release for once-daily dosing |
Delayed-release to overcome gastric acid irritation |
Controlled-release for localized steroid action |
|
Dosage Frequency |
Once daily |
2-3 times daily |
Once daily |
|
Side Effects |
Mild GI discomfort, headache |
Mild GI discomfort, headache |
Increased risk of infections, adrenal suppression |
|
Long-Term Use |
Safe for maintenance therapy |
Safe for maintenance therapy |
Not recommended for long-term use due to steroid effects |
|
Best For |
Patients preferring once-daily dosing |
Patients who need multiple doses |
Patients with moderate to severe inflammation not responding to 5-ASA |
Drug – Drug interaction
Before taking Mesacol OD Tablet, inform your doctor if you are taking any of the following medicine:
- sulphasalazine (medicine used to manage ulcerative colitis)
- non- steroidal anti-inflammatory drugs (medicines used to reduce fever and provide relief from pain) Ex. aspirin, ibuprofen, diclofenac
- azathioprine (used after transplantations or to manage autoimmune diseases)
- mercaptopurine (medicines used to manage leukemia)
- medicines used to manage blood clotting (Ex. warfarin)
Drug – Food interaction
High-Fat Meals
- May delay absorption of Mesacol OD, potentially affecting its effectiveness.
- It is recommended to take the tablet with a normal meal rather than a high-fat meal.
Dairy Products
- No major interaction, but some patients report stomach discomfort when taken with milk.
- If you experience bloating or discomfort, take it with water instead.
Caffeine and Carbonated Drinks
- May worsen gastrointestinal irritation in sensitive individuals.
- Limiting excessive caffeine or soda may help reduce stomach-related side effects.
Alcohol
- Increases the risk of stomach irritation and liver toxicity.
- Can worsen dizziness, nausea, and dehydration when taken with Mesacol OD.
Iron Supplements
- May interfere with Mesacol OD absorption, reducing its effectiveness.
- If iron supplementation is necessary, take it a few hours apart from Mesacol OD.
Antacids (Aluminum/Magnesium-based)
- Can alter the pH of the stomach, affecting the release and absorption of Mesacol OD.
- Avoid taking them together; maintain a 2-hour gap if needed.
Grapefruit Juice
- Although no direct interaction is established, grapefruit juice can affect drug metabolism and should be consumed in moderation.
For best results, follow a balanced diet and take Mesacol OD as directed by your doctor to avoid potential food-related interactions.
Synopsis
| Drug | : | Mesalamine |
| Pharmacological Category | : | Salicylates |
| Therapeutic Indication | : | Ulcerative colitis |
| Dosage Forms | : | Tablets, Oral disintegrating tablets, Suppositories, Sachet, Granules, Powder, Pellet, Enema |
More Information
How to Stop or Switch from Mesacol OD:
1. Do Not Stop Abruptly
- Stopping Mesacol OD suddenly can trigger a relapse of ulcerative colitis symptoms.
- Always consult your doctor before discontinuing or switching medications.
2. Tapering the Dose (If Required)
- Depending on your condition, your doctor may gradually reduce the dose instead of stopping it suddenly.
- A slow taper allows your body to adjust and prevent flare-ups.
3. Switching to Another Medication
- If your doctor prescribes a different medication (e.g., Mesacol, Budez CR, or biologics), they will guide you on how to transition.
- Some patients may need overlapping therapy for a smooth switch.
4. Monitoring for Symptoms
- After stopping or switching, watch for signs of relapse like diarrhea, abdominal pain, or blood in stools.
- If symptoms return, inform your doctor immediately.
5. Lifestyle and Diet Adjustments
| Weight | 25 g |
|---|
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