Introduction About VINGRAF 0.25 CAPSULE
VINGRAF 0.25 CAPSULE contains Tacrolimus which belongs to the group of medicines called Immunosuppressants. It is used to manage graft rejection in patients undergoing organ transplantation. It can also be used to manage an ongoing graft rejection of the newly transplanted organ. It is mostly used in combination with other immune suppressants to achieve maximum benefits.
Tacrolimus suppresses your body’s immune functions and enables your body to accept the transplanted organ. Take VINGRAF 0.25 CAPSULE regularly as instructed by your doctor. While undergoing therapy with VINGRAF 0.25 CAPSULE your doctor will periodically monitor your heart functions and nerve functions to avoid the risk of side effects.
Your doctor may also prescribe you blood tests and urine tests at regular intervals to access the improvement in your health conditions. During management with VINGRAF 0.25 CAPSULE, avoid exposing your skin towards direct sunlight. Wear protective loose-fitting clothes and apply sunscreen while going outdoors.
Before taking VINGRAF 0.25 CAPSULE inform your doctor if you have any liver, kidney or heart problems. Avoid consuming grapefruit or drinking grapefruit juice while taking VINGRAF 0.25 CAPSULE as it may increase the risk of side effects.
Do not take VINGRAF 0.25 CAPSULE without consulting your doctor if you are pregnant or breastfeeding. Both men and women taking VINGRAF 0.25 CAPSULE must use a suitable contraceptive method (such as condoms or oral contraceptive pills) to avoid pregnancy while undergoing therapy with VINGRAF 0.25 CAPSULE.
The most common side effects of taking VINGRAF 0.25 CAPSULE are an increase in blood sugar levels, increased blood cholesterol levels, difficulty in falling asleep, increased blood potassium levels, high blood pressure, headache, dizziness, indigestion, oedema and increased infections. Consult your doctor if any of these side effects worsen.
Uses Of VINGRAF 0.25 CAPSULE
- Prevents graft rejection following organ transplantation
How VINGRAF 0.25 CAPSULE Works
VINGRAF 0.25 CAPSULE is an immunosuppressive agent. It works by blocking the release of certain chemicals in the body (such as T-cells) that triggers the immune response. It suppresses your body’s immune functions and enables your body to accept the transplanted organ. As a result, it manages the risk of graft rejection and increases the survival of the newly transplanted organ.
How to use VINGRAF 0.25 CAPSULE
Take VINGRAF 0.25 CAPSULE 1 hour before meals or 2-3 hours after meals or as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight and disease condition. Do not stop taking VINGRAF 0.25 CAPSULE without consulting your doctor.
Side Effects Of VINGRAF 0.25 CAPSULE
Common
- increased blood sugar levels (diabetes)
- increased blood pressure
- increased potassium levels in the blood
- difficulty in falling asleep
- feeling shaky or trembling
- headache, dizziness
- liver problems, kidney problems
- nausea, vomiting
- stomach pain, diarrhea, constipation, bloating
- mouth ulcers
- low RBC and platelet count
- oedema (swelling of body parts)
- increased blood cholesterol levels
- feeling anxious, confused, disoriented or depressed
- fits, tingling and numbness of hands and feet
- eye sensitivity towards light, ringing sound in the ears
- abnormal or faster heartbeat
- skin rash and itching, acne, hair loss
- increased sweating
- pain in joints, limbs, back and feet, muscle spasms
- weight gain
- increased acidity in the blood
Rare
Stop taking VINGRAF 0.25 CAPSULE and contact your doctor immediately if you experience any of the following side effects such as:
- severe stomach pain with or without fever, chills, nausea and vomiting
- signs of skin cancer (such as growth or lump on the skin, dark patches on the skin, flesh-coloured or scar-like lesions, scaly patches on sun-exposed areas)
- signs of lymph cancer (enlarged lymph nodes with tiredness, fever, night sweats, itchy skin, weight loss)
- increased frequency of opportunistic infections (including skin infections, urinary tract infections, respiratory tract infections, stomach infections, oral infections, etc.)
- flu-like symptoms (such as fever, sore throat, cold, cough, feeling unwell)
- signs of brain infection (such as memory loss, difficulty in thinking, trouble in walking or vision loss)
- signs of kidney damage such as Haemolytic uraemic syndrome causing low urine output, extreme tiredness, yellowing of the skin or eyes and abnormal bruising or bleeding with signs of infection
- blurred vision, changes in colour of the vision or vision loss
- signs of allergic reactions (such as severe skin rash with itching, blistering and peeling of the skin, mouth, eyes, throat, genitals, swelling of the face and tongue, bleeding under the skin causing the appearance of red-pin point dots on the skin, skin swelling, along with fever, tiredness, confusion or jaundice)
- signs of heart problems (such as chest pain, vertigo, fainting, nausea, palpitations and difficulty in breathing)
How To Manage Side Effects
Nausea or vomiting:
Try to take VINGRAF 0.25 CAPSULE with or just after meals. Stick to simple meals and avoid oil-rich or spicy foods. Consult your doctor if the nausea worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Constipation:
Taking VINGRAF 0.25 CAPSULE with meals may reduce the chances of constipation. However, if you experience constipation, eat plenty of fiber-rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Warning & Precautions
Pregnancy
VINGRAF 0.25 CAPSULE should be used in pregnant women only if it is considered necessary by the physician. Therefore, inform your doctor before taking it. Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with VINGRAF 0.25 CAPSULE.
Breastfeeding
VINGRAF 0.25 CAPSULE may pass through breast milk. Therefore, it is not recommended for use in breastfeeding woman. However, consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any heavy tools or machines if you experience dizziness or sleepiness after taking VINGRAF 0.25 CAPSULE.
Alcohol
Avoid consumption of alcohol while taking VINGRAF 0.25 CAPSULE as it might make you feel dizzier or sleepy.
Kidney
VINGRAF 0.25 CAPSULE should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
Liver
VINGRAF 0.25 CAPSULE should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.
Allergy
Talk to your doctor before taking VINGRAF 0.25 CAPSULE if you are allergic to Tacrolimus or to any macrolide antibiotics (such as erythromycin, azithromycin).
Heart Disease
VINGRAF 0.25 CAPSULE should be used with caution in patients with heart problems (such as prolonged QT interval). Therefore, consult your doctor before taking it.
Others
Before taking VINGRAF 0.25 CAPSULE inform your doctor if you:
- are scheduled for any vaccination in the upcoming days
- high blood cholesterol levels
- have high blood potassium levels
Use in pediatrics:
The safety and effectiveness of VINGRAF 0.25 CAPSULE have not been established in children and adolescents (aged below 18 years) undergoing transplantation. Therefore, consult your doctor before taking it.
Use in geriatrics:
VINGRAF 0.25 CAPSULE should be used with caution in elderly patients. Therefore, consult your doctor before taking it.
| Weight | 11 g |
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