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COMBINIB 250mg Tablet 30’s
Original price was: ₹8,228.00.₹7,406.00Current price is: ₹7,406.00.
*30 Tablet(s) in a Bottle
* Delivery charges if applicable will be applied at checkout
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Introduction About COMBINIB 250MG TABLET
COMBINIB 250MG TABLET contains Lapatinib which belongs to the group of medicines called Anticancer agents. It is used to manage metastatic breast cancer (cancer that has been spread to other parts of the body from breast). It is mostly used in combination with other anticancer or hormonal medicines (such as capecitabine, trastuzumab or anastrozole) to achieve better results.
COMBINIB 250MG TABLET can be taken either one hour before or one hour after food. During management with COMBINIB 250MG TABLET, your doctor will periodically monitor your heart, liver, kidney and lung functions as a precaution.
Before taking COMBINIB 250MG TABLET, inform your doctor if you have any lung, liver, kidney or heart problems. You must also inform your doctor if you have diarrhea before taking this medicine.
Do not take COMBINIB 250MG TABLET without consulting your doctor if you are pregnant or breastfeeding. The most common side effects of taking COMBINIB 250MG TABLET are nausea, vomiting, weakness, indigestion, constipation, sore mouth, trouble sleeping, back pain, joint pain, headache, hot flushes, hair loss, nail disorder and abnormal heartbeat. Consult your doctor if any of these side effects worsen.
Uses Of COMBINIB 250MG TABLET
- Manage metastatic breast cancer
How COMBINIB 250MG TABLET Works
COMBINIB 250MG TABLET is an anticancer agent. It works by blocking the actions of certain cellular proteins (tyrosine kinase) that triggers cancer cell formation. It also blocks various downstream cell signalling pathways that triggers cancer growth within the body. As a result, it reduces cancer formation and manages its further growth within the body.
How to use COMBINIB 250MG TABLET
Take COMBINIB 250MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. COMBINIB 250MG TABLET can be taken either one hour before or one hour after food.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Continue to take COMBINIB 250MG TABLET for the stipulated duration instructed by your doctor to achieve better results.
Side Effects Of COMBINIB 250MG TABLET
Common
- nausea, vomiting, loss of appetite
- tiredness, weakness
- indigestion, constipation, stomach pain
- sore mouth, trouble sleeping
- back pain, pain in hands and feet, joint pain
- skin reaction on the palms of the hands or soles of the feet (including tingling, numbness, pain, swelling or reddening)
- headache
- nose bleeds, hot flushes
- unusual hair loss or thinning
- nail disorder
- abnormal heartbeat
Rare
Stop taking COMBINIB 250MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of allergic reactions (such as skin rash, itching, swelling of the face, lips, tongue and throat causing difficulty in breathing or swallowing)
- severe diarrhea
- severe skin rash with skin dryness and itching
- severe cough and shortness of breath (signs of lung damage)
How To Manage Side Effects
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Consult your doctor if your dizziness worsens.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Consult your doctor if your headache worsens.
Nausea And Vomiting
Stick to simple meals and avoid oil rich or spicy foods. Consult your doctor if nausea worsens.
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Skin rash Or Itching
Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.
Warning & Precautions
Pregnancy
Contraindicated
COMBINIB 250MG TABLET is not recommended for use in pregnant women. Therefore, consult your doctor for advice before taking it. Women of childbearing potential must use a suitable contraceptive method to manage pregnancy while taking COMBINIB 250MG TABLET.
Breastfeeding
Contraindicated
COMBINIB 250MG TABLET may pass through breast milk. Therefore, it is not recommended for use in breast-feeding women. Kindly consult your doctor before taking it.
Driving and Using Machines
Use with Caution
Do not drive or operate any machines if your ability is affected by COMBINIB 250MG TABLET.
Alcohol
Consult your doctor
Avoid consumption of alcohol while taking COMBINIB 250MG TABLET to avoid unwanted reactions.
Kidney
Use with Caution
COMBINIB 250MG TABLET should be used with caution in patients with kidney diseases. Therefore, consult your doctor before taking it.
Liver
Use with Caution
COMBINIB 250MG TABLET should be used with caution in patients with liver diseases. Therefore, consult your doctor before taking it.
Allergy
Contraindicated
Do not take COMBINIB 250MG TABLET if you are allergic to Lapatinib.
Lungs
Use with Caution
COMBINIB 250MG TABLET should be used with caution in patients with lung diseases or inflammation. Therefore, consult your doctor before taking it.
Heart Disease
Use with Caution
COMBINIB 250MG TABLET should be used with caution in patients with heart problems. Therefore, consult your doctor before taking it.
Use In Pediatrics
Contraindicated
COMBINIB 250MG TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
Use In Geriatrics
Use with Caution
COMBINIB 250MG TABLET should be used with caution in elderly patients (aged 65 years or older). Therefore, consult your doctor before taking it.
Others
Before taking COMBINIB 250MG TABLET, inform your doctor if you:
- have diarrhea
Interactions
A. Drug – Drug interactions:
Before taking COMBINIB 250MG TABLET inform your doctor if you are taking any of the following medicines such as:
- St. John’s Wort (an herb medicine used to manage depression)
- medicines used to manage bacterial infections (such as erythromycin, , rifabutin, rifampicin, telithromycin)
- medicines used to manage fungal infections (such as ketoconazole, itraconazole, posaconazole, voriconazole)
- medicines used to manage viral infections (such as ritonavir, saquinavir)
- cyclosporine (a medicine used to suppress the immune system)
- medicines used to manage epilepsy (such as phenytoin, carbamazepine)
- cisapride (a medicine used to manage stomach problems)
- pimozide (a medicine used to manage psychiatric illnesses)
- medicines used to manage irregular heart rate (such as quinidine, digoxin)
- repaglinide (a medicine used to manage diabetes)
- verapamil (a medicine used to manage high blood pressure or angina)
- nefazodone (a medicine used to manage depression)
- other medicines used to manage cancer (such as topotecan, paclitaxel, irinotecan, docetaxel)
- rosuvastatin (a medicine used to manage high blood cholesterol levels)
- medicines used to manage stomach ulcers (such as omeprazole, pantoprazole, ranitidine, cimetidine)
2. Drug – Food interaction:
Do not drink grapefruit juice while taking this medicine, as it may reduce its effectiveness.
Over dosage:
If you or anyone else accidentally took more COMBINIB 250MG TABLET, consult your doctor immediately or visit the nearby hospital
Synopsis
| Drug | :Â Â | Lapatinib |
| Pharmacological Category | :Â Â | Protein Tyrosine Kinase Inhibitor |
| Therapeutic Indication | :Â Â | Breast cancer |
| Dosage Forms | :Â Â | Tablet |
More Information
- Keep COMBINIB 250MG TABLET out of reach of children
- Store COMBINIB 250MG TABLET at room temperature
FAQs About COMBINIB 250MG TABLET
Q: How does COMBINIB 250MG TABLET works?
A: COMBINIB 250MG TABLET is an anticancer agent. It works by blocking the actions of certain cellular proteins (tyrosine kinase) that triggers cancer cell formation. It also blocks various downstream cell signalling pathways that triggers cancer growth within the body. As a result, it reduces cancer formation and manages its further growth within the body.
Q: Can I take COMBINIB 250MG TABLET during breastfeeding?
A: No. COMBINIB 250MG TABLETÂ is not recommended for use in breast-feeding women. Therefore, consult your doctor before taking.
Q: Can COMBINIB 250MG TABLET cause headache?
A: Yes. COMBINIB 250MG TABLET may cause headache in some individuals. If you experience headache, rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume alcohol. Consult your doctor if your headache worsens.
Q: Can COMBINIB 250MG TABLET increase the risk of infections?
A: COMBINIB 250MG TABLET may cause a drop in the number of white blood cells in the body and may weaken your immune system. As a result, you may be at greater risk of getting infected while
taking COMBINIB 250MG TABLET. To avoid this, your doctor will regular monitor your blood counts as a precaution. However, inform your doctor if you experience any signs of infection such as fever.
Q: Can the use of COMBINIB 250MG TABLET make me feel tired?
A: Yes. COMBINIB 250MG TABLET may make you feel tired easily. This is because, it reduces the levels of red blood cells in your blood and may make you anaemic. Consult your doctor if you experience tiredness after taking COMBINIB 250MG TABLET. Tiredness can also occur if you have any pre-existing disease conditions such as liver or kidney impairment while taking this medicine.
Q: Can I drive a car after taking COMBINIB 250MG TABLET?
A: COMBINIB 250MG TABLET may make you feel tired or dizzy. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by COMBINIB 250MG TABLET.
Q: How to take COMBINIB 250MG TABLET?
A: Take COMBINIB 250MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. COMBINIB 250MG TABLET can be taken either one hour before or one hour after food.
Q: What should I do if I forget to take a dose of COMBINIB 250MG TABLET?
A: If you forget to take a dose of COMBINIB 250MG TABLET, or vomited immediately after taking the dose, take it as soon as you remember. Do not take the medicine twice to make up for the forgotten dose.
Q: How to control nausea caused due to COMBINIB 250MG TABLET?
A: Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them along with COMBINIB 250MG TABLET. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-manage nausea.
References
1. Goodman & Gilman’s: The Pharmacological Basics of Therapeutics. 12th Edition. 2011. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies and Cytokines. Page -1737.
2. Frans L. Opdam,a,b Henk-Jan Guchelaar,b Jos H. Beijnen,c,d and Jan H.M. Schellens. Lapatinib for Advanced or Metastatic Breast Cancer. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. April 2012. [Accessed on 10th February 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336826/
3. Novartis Pharma GmbH. Tyverb® 250 mg film-coated tablets lapatinib. Electronics Medicines Compendium. [Revised in March 2022]. [Accessed on 10th February 2023] https://www.medicines.org.uk/emc/files/pil.6292.pdf
4. Central Drugs Standard Control Organization. Lapatinib (as Ditosylate) (250mg) Tablet. July 2007. Lapatinib Ditosylate Tablets 250mg (addl. Indication). May 2010. Lapatanib tablet 250mg (Additional indication). December 2014. [Accessed on 10th February 2023] https://cdscoonline.gov.in/CDSCO/Drugs
| Weight | 50 g |
|---|
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