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Saaz DS Tablet 10’S
Original price was: ₹175.00.₹167.00Current price is: ₹167.00.
Introduction About SAAZ DS TABLET
Saaz DS Tablet 10’S
is a prescription medication used for the management of rheumatoid
arthritis, ulcerative colitis, and Crohn’s disease. It helps reduce
inflammation and relieve symptoms effectively.
Your doctor might
want you to take certain blood, kidney and liver function tests during
the management. Drink enough fluids during this management to avoid
problems with kidney.
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Uses Of SAAZ DS TABLET
It is used to manage:
- Ulcerative colitis
- Crohn’s disease
- Rheumatoid arthritis
Benefits of SAAZ DS TABLET
1. Reduces Inflammation
- Helps control joint inflammation in rheumatoid arthritis (RA), reducing pain and swelling.
- Acts on the intestines to reduce inflammation in ulcerative colitis and Crohn’s disease?
2. Saaz DS for Rheumatoid Arthritis
- Classified as a Disease-Modifying Anti-Rheumatic Drug (DMARD), meaning it prevents joint damage and long-term disability in arthritis patients?
3. Supports Gut Health in IBD (Inflammatory Bowel Disease)
- The 5-aminosalicylic acid (5-ASA) component of Saaz DS helps in healing the gut lining and reducing symptoms of diarrhea, abdominal pain, and bleeding?
4. Immunomodulatory Effect
- Suppresses overactive immune responses, preventing the immune system from attacking healthy joint or gut tissues in autoimmune disorders?.
5. Effective Long-Term Management
- When taken consistently, Saaz DS can help patients achieve remission in ulcerative colitis and prevent flare-ups?
6. Alternative to Steroids
Often prescribed as an alternative to corticosteroids, which have more severe long-term side effects
How SAAZ DS TABLET Works
Saaz
DS (Sulfasalazine) is a disease-modifying anti-rheumatic drug (DMARD)
that works primarily by targeting inflammation in the body, especially
in the joints and digestive tract
Mechanism of Action:
- Anti-inflammatory Action: Saaz DS contains sulfasalazine, which breaks down in the body to produce 5-aminosalicylic acid (5-ASA) and sulfapyridine. The 5-ASA component is primarily responsible for the anti-inflammatory effects. It acts by:
- Inhibiting inflammatory cytokines: 5-ASA reduces the production of inflammatory molecules like prostaglandins and leukotrienes, which are responsible for causing inflammation.
- Suppressing immune response: It can dampen the activation of certain immune cells, thereby helping to control autoimmune reactions, especially in conditions like rheumatoid arthritis and ulcerative colitis.
- Modulation of Immune Response: Sulfasalazine and its metabolites, particularly sulfapyridine,
have immune-modulating effects that help reduce the overactivity of the
immune system that is typical in conditions like rheumatoid arthritis.
It decreases T-cell activation, macrophage function, and the release of interleukins, which are involved in the inflammatory process. - Impact on the Gastrointestinal Tract:
- In conditions like ulcerative colitis and Crohn’s disease, Saaz DS works directly on the intestines,
reducing inflammation and promoting healing of the digestive lining.
This is particularly useful in conditions where the immune system
mistakenly attacks the gastrointestinal system. - The 5-ASA released in the colon targets the inflammation specific to the intestines, leading to improved symptom control in IBD (Inflammatory Bowel Disease).
- In conditions like ulcerative colitis and Crohn’s disease, Saaz DS works directly on the intestines,
- Reduction in Joint Inflammation: In rheumatoid arthritis,
Saaz DS works by modulating the immune system’s response, reducing
joint inflammation, and preventing further damage to the joints. It can
also help reduce the need for steroids or other stronger medications.
How to use SAAZ DS TABLET
1.Recommended Dosage for Adults
- Rheumatoid Arthritis:
Typically, the dose is 500 mg to 1,000 mg, taken once or twice a day,
depending on the severity of the condition. The dosage may be gradually
increased by your doctor. - Ulcerative Colitis:
The usual dosage is 1,000 mg to 2,000 mg per day, divided into two
doses. Again, this can vary based on your physician’s recommendation
based on your condition’s severity. - Always follow your doctor’s instructions on the exact dosage.
2. Can Saaz DS be Taken on an Empty Stomach?
- Swallow the tablet whole with a glass of water.
- It can be taken with food or on an empty stomach, depending on how it affects your stomach.
- It is often advised to take it after a meal if gastrointestinal discomfort occurs.
3. How long should one take Saaz DS Tablet?
- Chronic Conditions:
Treatment is usually long-term, and it may take several weeks to notice
the full benefits, especially for conditions like rheumatoid arthritis
or ulcerative colitis. - Continuous Monitoring:
Regular blood tests (for liver and kidney function) and monitoring for
side effects like blood disorders are necessary during treatment.
4. How Soon Does Saaz DS Start Working?
For Rheumatoid Arthritis:
- Initial Effects: Sulfasalazine may start providing some symptom relief within 2 to 4 weeks of starting the medication. However, it can take up to 12 weeks for the full therapeutic effects to be noticed.
- Long-Term Use:
It often takes longer for Saaz DS to significantly reduce joint
inflammation, pain, and stiffness, especially in chronic conditions like
rheumatoid arthritis.
 For Ulcerative Colitis:
- Onset of Action: In treating ulcerative colitis, some patients may notice improvements within 2 to 4 weeks, but for the drug to provide significant control over flare-ups, it can take up to 6 to 8 weeks.
- Maintenance:
Once the medication begins to work, it can help maintain remission,
reducing the frequency and severity of flare-ups over the long term.
For Crohn’s Disease:
- Similar to ulcerative colitis, the onset of effects may take 4 to 6 weeks, though some patients may require several months to experience maximum benefit.
5. Can I stop taking Saaz DS suddenly?
- No, Saaz DS (Sulfasalazine)
should not be stopped suddenly without consulting a healthcare
provider. Stopping the medication abruptly, especially for conditions
like rheumatoid arthritis, ulcerative colitis, or Crohn’s disease, can lead to a flare-up of symptoms or worsening of the condition.
- Always
talk to your doctor before stopping Saaz DS. They will guide you on the
appropriate method to discontinue or adjust your medication, especially
if you are experiencing side effects or if your condition has improved. - In
some situations, if you’re no longer experiencing symptoms, your doctor
may slowly taper the dosage to minimize the risk of flare-ups.
6. Is Saaz DS Safe for Long-Term Use?
Saaz DS (Sulfasalazine) is generally considered safe for long-term use when prescribed by a healthcare provider and when used to manage chronic conditions like rheumatoid arthritis, ulcerative colitis, or Crohn’s disease. However, long-term use should always be monitored closely due to potential side effects and risks.
Safety Considerations for Long-Term Use:
Potential Side Effects:
- Gastrointestinal Issues:
Some people experience nausea, vomiting, or abdominal pain, especially
when starting the medication. These effects typically lessen over time. - Hematological Effects: Sulfasalazine can occasionally cause blood disorders such as low white blood cell count (leukopenia), anemia, or thrombocytopenia. Regular blood tests are recommended to monitor for these issues.
- Liver Toxicity: Prolonged use may sometimes affect liver function. It is important to have liver function tests performed regularly, particularly in those with pre-existing liver conditions.
- Pulmonary Issues: Rarely, Sulfasalazine has been associated with pulmonary toxicity, leading to breathing difficulties or lung damage. This can be more problematic in individuals with pre-existing lung disease.
Monitoring for Long-Term Safety:
- Regular Check-ups: Long-term users should have periodic blood tests, including complete blood counts (CBC) and liver function tests, to detect early signs of any side effects.
- Kidney Function: Monitoring kidney function is also crucial, as Saaz DS is metabolized by the liver and excreted through the kidneys.
- Eye Health: While rare, eye problems such as retinal toxicity can occur, so monitoring eye health during long-term use may be advised in some cases.
What if I forgot to take SAAZ DS TABLET
- If you miss a dose, take it as soon as you remember.
- If the next dose is near, skip the missed dose—do not take two doses at once to make up for the missed one.
Side Effects Of SAAZ DS TABLET
Like all medicines, Saaz DS Tablet may cause certain side effects in some individuals, although not everybody gets them.
Some of the Common Side Effects of Saaz DS Tablet are:
- indigestion
- heartburn
- nausea
- dizziness
- headache
- changes in taste
- ringing in the ears
- cough
- itching of the skin
- purple discolorations on the skin
- joint pain
- protein in urine
- fever
Serious Side Effects (When to Seek Medical Help):
- allergic
reaction such as sudden wheeziness, difficulty in breathing, swelling
of eyelids, face or lips, rash or itching (affecting the whole body) - jaundice
- severe
skin rash that causes blistering (affects the mouth and tongue),
life-threatening skin rashes (exfoliate dermatitis, Stevens-Johnson
syndrome, toxic epidermal necrolysis) - fever, pains in your joints, hives, swollen glands, rash and itching (signs of serum sickness)
- any unexplained bleeding
- bruising, fever, rash, pallor (paleness), severe sore throat or tiredness (signs of abnormality in blood)
- rash or fever or swollen gland may be a sign of DRESS (drug rash with eosinophilia and systemic symptoms)
How To Manage Side Effects
Cough And Cold
- Honey:
Honey has soothing properties that can help reduce throat irritation
and suppress cough. Take a spoonful of raw honey or mix it into warm
tea. - Hydration: Keep your throat moist by drinking warm fluids like tea with honey or water.
- Steam Inhalation: Breathing in steam from a hot shower or a bowl of hot water can loosen mucus and relieve a dry or wet cough.
- Cough
Syrup: Over-the-counter cough syrups or lozenges can help calm
coughing, especially if it’s due to irritation or minor throat
inflammation.
Headache
- Hydration: Dehydration is a common cause of headaches. Drink plenty of water to stay hydrated.
- Rest: Ensure adequate rest, as lack of sleep can contribute to headaches.
- Cold
or Warm Compress: Applying a cold compress to the forehead or a warm
compress to the back of the neck can alleviate tension headaches. - Over-the-Counter
Pain Relief: Ibuprofen, acetaminophen, or aspirin can help relieve mild
to moderate headaches. However, consult a doctor if headaches are
frequent or severe.
Indigestion
- Avoid Trigger Foods: Spicy, fatty, or acidic foods can trigger indigestion. Try to avoid them until symptoms subside.
- Eat Slowly: Eating too quickly can lead to indigestion. Take smaller bites and chew your food thoroughly.
- Antacids: Over-the-counter medications like antacids can help neutralize stomach acid and provide relief.
- Herbal Teas: Peppermint tea or chamomile tea may help relax the stomach muscles and reduce discomfort.
Nausea And Vomiting
- Ginger: Known for its anti-nausea properties, ginger tea or ginger supplements can soothe an upset stomach.
- Small, Frequent Meals: Eating smaller meals more frequently throughout the day can prevent nausea. Avoid large or greasy meals.
- Stay Upright: After eating, avoid lying down, as this can worsen nausea.
- Fresh Air: Sometimes, stepping outside for fresh air can help relieve the sensation of nausea.
Warning & Precautions
Pregnancy
Consult your doctor
Inform
your doctor if you are pregnant or planning to have a baby before
taking SAAZ DS TABLET. Your doctor will decide whether to take it or
not.
Breastfeeding
Consult your doctor
Avoid
breastfeeding while taking SAAZ DS TABLET as there have been reports of
diarrhea or blood in the stools in nursing babies. Consult your doctor
before taking it.
Driving and Using Machines
Safe
SAAZ DS TABLET is unlikely to affect your ability to drive or use machines.
Kidney
Use with Caution
SAAZ
DS TABLET should be used with caution in patients with kidney disease.
Consult your doctor before taking. It’s important to regularly monitor serum creatinine levels, glomerular filtration rate (GFR), and electrolyte levels to ensure the kidneys are functioning properly and to adjust medications accordingly.
Liver
Use with Caution
SAAZ DS TABLET should be used with caution in patients with liver disease. Consult your doctor before taking. Liver function tests (LFTs) should be regularly monitored to assess whether the liver is handling medications effectively.
Allergy
Contraindicated
Do
not take SAAZ DS TABLET if you are allergic to Sulfasalazine,
salicylates (Ex. aspirin) or sulfonamides (type of antibiotic) or any
other ingredients of this medicine.
Lungs
Use with Caution
SAAZ DS TABLET should be used with caution in patients with asthma. Consult your doctor before taking.
Use In Pediatrics
Consult your doctor
Children
and adolescents aged below 18 years must consult your doctor before
taking SAAZ DS TABLET. It is not recommended for use in children below 2
years of age. Hence, consult your doctor for a suitable alternative.
Use In Geriatrics
Use with Caution
SAAZ DS TABLET should be used with caution in elderly patients. Consult your doctor before taking.
Other Warnings for SAAZ DS TABLET
Before taking SAAZ DS TABLET, inform your doctor if you:
- have blood disorders
- have glucose-6-phosphate dehydrogenase deficiency (an inherited condition)
- have a history of recurring chronic infections
- your child has arthritis
Who should not take [GBNKEYWORD
- have porphyria (a rare blood pigment disorder)
- have jaundice
Diet and Lifestyle Advice
1. Diet Recommendations:
A
healthy diet is essential for supporting the immune system and managing
symptoms associated with conditions treated by Saaz DS.
For Rheumatoid Arthritis:
- Anti-inflammatory foods:
Incorporate foods rich in omega-3 fatty acids (like salmon, chia seeds,
and walnuts), fiber, and antioxidants (found in fruits, vegetables, and
whole grains) to reduce inflammation. - Avoiding triggers: Some
people with autoimmune diseases may benefit from avoiding foods that
could exacerbate inflammation, such as processed sugars, refined
carbohydrates, and saturated fats.
For Ulcerative Colitis:
- Low-fiber and bland foods during flare-ups:
Foods that are easy to digest, like white rice, applesauce, and
bananas, may help during flare-ups. This reduces irritation to the
digestive tract. - Probiotics: Foods like yogurt
and fermented foods (kimchi, sauerkraut) can support gut health, but
it’s important to consult your doctor before introducing them,
especially during active flare-ups.
For Crohn’s Disease:
- Balanced meals: A diet rich in lean proteins (chicken, tofu), low-fat dairy, and well-cooked vegetables can help avoid digestive irritation.
- Nutrient-dense foods:
Crohn’s disease can lead to malabsorption, so focusing on
nutrient-dense foods such as leafy greens, legumes, and smooth nut
butters can help fill nutrient gaps.
2. Exercise Recommendations:
Exercise
can significantly improve joint health, mobility, and overall physical
well-being. The key is to balance low-impact activities with those that
enhance flexibility and strength.
For Rheumatoid Arthritis:
- Low-impact activities:
Exercises like swimming, cycling, and walking can reduce strain on the
joints while improving flexibility and cardiovascular health. - Strength training:
Incorporating light resistance exercises (e.g., resistance bands, light
weights) helps build muscle strength around the joints, supporting
their function and reducing the risk of further joint damage.
For Ulcerative Colitis and Crohn’s Disease:
- Moderate exercise:
Low to moderate exercises like yoga, walking, and cycling can help
improve digestive function, reduce stress, and maintain overall health. - Manage flare-ups:
During flare-ups of inflammatory bowel diseases (IBD), rest is crucial,
but gentle stretching and walking may help with overall recovery.
3. Lifestyle Changes:
Certain lifestyle changes can enhance the effectiveness of Saaz DS and improve quality of life.
Stress Management:
- Mind-body
techniques like yoga, deep breathing, and meditation can reduce stress,
which is known to exacerbate both autoimmune diseases and
gastrointestinal conditions. Chronic stress increases inflammation in
the body, so managing it can help improve symptoms. - Adequate sleep: Getting 7-9 hours of sleep each night is crucial for immune system regulation and overall health.
Regular Medical Check-ups:
- Stay
up-to-date with routine check-ups, especially for people on long-term
medications like Saaz DS. Regular blood tests to monitor for side
effects like liver or kidney function, or blood count issues, are
crucial. - If you experience side effects or new symptoms, talk to your healthcare provider promptly.
Smoking and Alcohol:
- Avoid smoking as it increases the risk of flare-ups in autoimmune diseases and negatively affects lung health and circulation.
- Limit alcohol consumption, as it can irritate the gastrointestinal tract and interact negatively with medications like Saaz DS.
Drug – Drug interaction
Methotrexate:
Both
Sulfasalazine and Methotrexate are immunosuppressive agents. When taken
together, there is an increased risk of bone marrow suppression, which
can lead to lower white blood cell counts, anemia, and thrombocytopenia.
Warfarin (Coumadin):
Sulfasalazine
can enhance the effects of Warfarin, increasing the risk of bleeding.
This is because Sulfasalazine can alter vitamin K metabolism, which is
critical for clotting.
Antacids and Iron Supplements:
Antacids
and iron supplements can reduce the absorption of Sulfasalazine in the
gastrointestinal tract, making the medication less effective.
Aspirin and Nonsteroidal Anti-Inflammatory Drugs (NSAIDs):
Both
Sulfasalazine and NSAIDs can potentially cause gastric irritation or
ulcers, and taking them together can increase the risk of
gastrointestinal bleeding.
Azathioprine:
Azathioprine
and Sulfasalazine are both immunosuppressants, and taking them together
may increase the risk of infections or bone marrow suppression.
Synopsis
| Drug | :Â Â | Sulfasalazine |
| Pharmacological Category | :Â Â | Anti-inflammatory |
| Therapeutic Indication | :  | Ulcerative colitis, Crohn’s disease, Rheumatoid arthritis |
| Dosage Forms | :Â Â | Tablet |
FAQs About SAAZ DS TABLET
Q: What are the common side effects of Saaz DS?
A:
Saaz DS (Sulfasalazine) is generally well-tolerated, but like any
medication, it can cause side effects. Some common side effects include:
Gastrointestinal issues: nausea, vomiting, abdominal pain, diarrhea,
and flatulence (gas), Headaches, Dizziness or lightheadedness, Loss of
appetite.
Q: Does Saaz DS cause nausea or vomiting?
A:
Yes, nausea and vomiting are known side effects of Saaz DS, especially
during the initial stages of treatment or when the dosage is increased.
These symptoms usually lessen over time as the body adjusts to the
medication. If nausea and vomiting become severe or persistent, it’s
essential to consult a doctor to determine if dose adjustments or an
alternative treatment are necessary.
Q: Can Saaz DS cause headaches or dizziness?
A:
Yes, headaches and dizziness are possible side effects of Saaz DS.
These are typically mild and may improve as your body adapts to the
medication. However, if these symptoms persist or worsen, or if they
interfere with your daily activities, it’s advisable to consult your
healthcare provider.
Q: Are there any severe allergic reactions to Saaz DS?
A:
Yes, severe allergic reactions are possible, though rare. Signs of a
serious allergic reaction include:Rash or hives, Swelling of the face,
lips, tongue, or throat, Difficulty breathing and Severe dizziness.
If
any of these symptoms occur, it is important to seek emergency medical
attention immediately, as they may indicate a serious reaction like
anaphylaxis.
Q: Does Saaz DS cause skin rashes or sensitivity?
A:
Yes, skin rashes are a known side effect of Saaz DS. Some individuals
may experience a mild rash, while others may have more significant skin
reactions. Photosensitivity (increased sensitivity to sunlight) is also
possible, which may make the skin more prone to sunburn. To manage this,
it’s important to use sunscreen or protective clothing when exposed to
sunlight.
Q: Can Saaz DS be taken with painkillers like ibuprofen?
A:
Saaz DS (Sulfasalazine) can interact with painkillers like ibuprofen,
and caution is advised. Both Saaz DS and NSAIDs (nonsteroidal
anti-inflammatory drugs like ibuprofen) can increase the risk of
gastrointestinal issues, including ulcers or bleeding, and may cause
kidney damage when used together. Therefore, it’s important to consult
your doctor before using them simultaneously.
Q: Does Saaz DS interact with methotrexate or digoxin?
A:
Methotrexate: Saaz DS and methotrexate are both immunosuppressive
drugs, and taking them together increases the risk of bone marrow
suppression and liver damage. Close monitoring of blood counts and liver
function is recommended when using these medications together.
There is no significant interaction between Saaz DS and digoxin.
However, it’s always advisable to monitor for any unexpected symptoms or
changes, especially related to kidney function since Saaz DS can affect
renal health.
Q: Are there any food restrictions while taking Saaz DS?
A:
There are no specific food restrictions while taking Saaz DS. However,
some patients find that their gastrointestinal symptoms (e.g., nausea,
abdominal pain) can be alleviated by taking the medication with food. It
is also recommended to avoid alcohol, as it can increase the risk of
liver toxicity or gastrointestinal irritation when combined with Saaz
DS.
Q: Can Saaz DS be taken with other arthritis medications?
A:
Yes, Saaz DS can be taken with other medications for arthritis,
including methotrexate and hydroxychloroquine. However, combining
multiple immunosuppressive drugs increases the risk of infections and
bone marrow suppression. Your healthcare provider will monitor your
blood counts and kidney function when combining these medications.
Q: Does Saaz DS interfere with diabetes medications?
A:
There is no direct interaction between Saaz DS and diabetes medications
like insulin or oral antidiabetic drugs (e.g., metformin). However,
since Saaz DS can affect kidney function, which is crucial for
metabolism and clearance of medications, it’s important to monitor renal
function when taking it with diabetes medications.
Q: Can I take Saaz DS Tablet without a prescription?
 A: No, this is a prescription medication. Consult a doctor before use.
Q: How long does it take for Saaz DS Tablet to work?
 A: It may take a few weeks to see full benefits. Follow your doctor’s guidance.
Q: What is SAAZ DS TABLET used for?
A:
SAAZ DS TABLET is used to manage inflammation caused by rheumatoid
arthritis or inflammatory bowel disease (ulcerative colitis, Crohn’s
disease). You must talk to a doctor if you do not feel better or if you
feel worse.
Q: Can SAAZ DS TABLET be used in children?
A:
SAAZ DS TABLET is not recommended for use in children below 2 years of
age. It is not recommended if you have systemic-onset juvenile
rheumatoid arthritis (Stills disease). Consult your doctor before
taking.
Q: What if I take more of SAAZ DS TABLET accidentally?
A:
If you or anyone else accidentally take too much of SAAZ DS TABLET,
consult your doctor immediately or visit the nearby hospital. Symptoms
of overdose are nausea and vomiting.
Q: How does SAAZ DS TABLET work?
A:
SAAZ DS TABLET works by suppressing the overactivity of the immune
system in autoimmune diseases and blocks the chemical messengers that
cause inflammation (swelling).
Q: Any tests to be taken while on management with SAAZ DS TABLET?
A:
Your doctor will take blood tests to check your blood, urine (for
protein), kidneys before you start management with SAAZ DS TABLET and
regularly during management.
Q: Is Saaz DS a painkiller or a steroid?
A:
Saaz DS (Sulfasalazine) is neither a painkiller nor a steroid. It is a
disease-modifying anti-rheumatic drug (DMARD) and an anti-inflammatory
medication. Sulfasalazine works by suppressing the immune system and
reducing inflammation in the body, particularly in the joints and
gastrointestinal tract, rather than directly relieving pain like
traditional painkillers (e.g., acetaminophen or ibuprofen).
References
1. KD Tripathi. Drugs for Constipation and Diarrhea. Essentials of medical pharmacology. Eighth Edition. 2019. Page –734-735.
2. Jaehwa Choi, Ardy Fenando. Sulfasalazine. [Revised on June 2021] [Accessed on 13th February 2025]Â 
3. Sanford L. Taffet MD & Kiron M. Das. Adverse effects and desensitization. [Accessed on 13th February 2025]Â
4. Pfizer Limited. Electronic Medicines Compendium (EMC). [Revised in December 2021] [Accessed on 13th February 2025]Â
6. Sulfasalazine. Drugs.com. [Revised in June 2022] [Accessed on 13th February 2025]Â
| Weight | 17.5 g |
|---|
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