- 6%
Endoxan N 200mg Injection 1’s
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INTRODUCTION ABOUT ENDOXAN N 200MG INJECTION
ENDOXAN N 200MG INJECTION contains Cyclophosphamide, which belongs to a group of medicines called Cytotoxic agents or Anti-cancer agents. It is indicated for malignant diseases in adults and children (such as malignant lymphomas, Hodgkin’s disease, Non-Hodgkin’s lymphoma, lymphocytic lymphoma mixed-cell type lymphoma, histiocytic lymphoma, Burkitt’s lymphoma, multiple myeloma, chronic lymphocytic leukemia, chronic granulocytic leukemia, acute myelogenous and monocytic leukemia, acute lymphoblastic leukemia, mycosis fungoides, neuroblastoma, adenocarcinoma of the ovary, retinoblastoma, Ewing’s sarcoma, breast cancer. It is also used for minimal change nephrotic syndrome in children.
ENDOXAN N 200MG INJECTION is not recommended for use in patients with acute infections, bone-marrow aplasia, urinary tract infections like cystitis, acute urothelial toxicity from cytotoxic chemotherapy or radiation therapy, urinary outflow obstruction, or unmanageed infections. Before receiving ENDOXAN N 200MG INJECTION inform your doctor if you are allergic or have anaphylactic reactions, bone marrow suppression, neutropenic fever, serious infections, severe immune suppression, concomitant chemotherapy and/or radiation therapy, urinary tract and renal diseases, heart diseases, pneumonitis, pulmonary fibrosis, pulmonary veno-occlusive disease, respiratory failure, pneumonitis and secondary malignancies, veno-occlusive liver disease, SIADH (syndrome of inappropriate secretion of antidiuretic hormone), rare hereditary problems of fructose intolerance, galactose intolerance, glucose-galactose malabsorption, Lapp lactase deficiency, sucrase-isomaltase insufficiency, adrenal insufficiency, diabetes and poor general health.
ENDOXAN N 200MG INJECTION is not recommended for use by pregnant women. It is generally not recommended for use in breastfeeding women as it may pass through the breast milk. ENDOXAN N 200MG INJECTION should be used with caution in children and adolescents. It should be used with caution in elderly patients. The most common side effects of receiving ENDOXAN N 200MG INJECTION are nausea, vomiting, weight loss, alopecia, hematuria and leukopenia. Contact your doctor if any of your symptoms gets worse or persists for a long duration.
USES OF ENDOXAN N 200MG INJECTION
It is used for:
- malignant diseases in adults and children
- minimal change nephrotic syndrome in children
HOW ENDOXAN N 200MG INJECTION WORKS
ENDOXAN N 200MG INJECTION works by interfering with the malignant cell growth by cross-linking of cancer cells DNA. ENDOXAN N 200MG INJECTION also transfers alkyl groups to DNA during the process of cell division, thus managing the normal synthesis of DNA. Therefore it works against the growth and multiplication of cancer cells.
DIRECTIONS FOR USE
ENDOXAN N 200MG INJECTION will be administered only by a doctor or a nurse into a vein as an intravenous injection or infusion. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
SIDE EFFECTS OF ENDOXAN N 200MG INJECTION
COMMON
- nausea, vomiting
- weight loss
- alopecia (hair loss)
- hematuria
- leukopenia (decrease in white blood cells)
UNCOMMON
- diarrhea
- darkening of skin/fingernails
- stomatitis
- anorexia
- headache
- diaphoresis
- gonadal suppression
- hyperuricemia
- impaired wound healing
- amenorrhea, premature menopause
RARE
- Pain and redness at the injection site
Stop receiving ENDOXAN N 200MG INJECTION and contact your doctor immediately if you experience any of the following side effects:
- Allergic reactions such as anaphylaxis, swelling of the face, lips, ankles/legs causing shortness of breath
- Palpitations
- Weight gain, dizziness or loss of consciousness
- Signs of infection include fever, sore throat, cold and cough
- Signs of bleeding from gums, bruising and petechiae due to a decrease in platelet count
- Haematuria (blood in urine)
HOW TO MANAGE SIDE EFFECTS
Diarrhea
Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not take any medicine on your own for managing diarrhea. Contact your doctor if the symptom did not improve.
Headache
Rest and relax. Drink plenty of fluids such as water and electrolytes. Apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the symptom did not improve.
Nausea And Vomiting
Take the medicine, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food.
WARNING & PRECAUTIONS
PREGNANCY
Contraindicated
ENDOXAN N 200MG INJECTION is generally not recommended for use in pregnant women. Consult your doctor before receiving ENDOXAN N 200MG INJECTION.
BREASTFEEDING
Contraindicated
ENDOXAN N 200MG INJECTION is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before receiving ENDOXAN N 200MG INJECTION.
DRIVING AND USING MACHINES
Use with Caution
Do not drive or operate any machinery if you feel dizziness, blurred vision, and visual impairment after receiving ENDOXAN N 200MG INJECTION.
ALCOHOL
Consult your doctor
Avoid consumption of alcohol while receiving ENDOXAN N 200MG INJECTION as it increases nausea and vomiting caused by ENDOXAN N 200MG INJECTION.
KIDNEY
Consult your doctor
ENDOXAN N 200MG INJECTION is not recommended if you have kidney or bladder problems as a result of previous chemotherapy or radiotherapy. It should be used with caution in patients with kidney diseases. Contact your doctor before receiving ENDOXAN N 200MG INJECTION.
LIVER
Use with Caution
ENDOXAN N 200MG INJECTION should be used with caution in patients with liver diseases. Contact your doctor before receiving ENDOXAN N 200MG INJECTION.
ALLERGY
Use with Caution
Do not receive ENDOXAN N 200MG INJECTION if you are allergic to Cyclophosphamide or any other ingredients of this medicine.
LUNGS
Use with Caution
[GBNEYWORD] should be used with caution in patients with lung diseases such as pneumonia, pulmonary fibrosis, pulmonary venous-occlusive disease, respiratory failure, and pneumonitis. Contact your doctor before receiving ENDOXAN N 200MG INJECTION.
HEART DISEASE
Use with Caution
ENDOXAN N 200MG INJECTION should be used with caution in patients with heart disease such as myocarditis, myopericarditis, and pericardial effusion including cardiac tamponade, congestive heart failure, ventricular arrhythmias. Contact your doctor before receiving ENDOXAN N 200MG INJECTION.
USE IN PEDIATRICS
Use with Caution
ENDOXAN N 200MG INJECTION should be used with caution in children. Contact your doctor before receiving ENDOXAN N 200MG INJECTION.
USE IN GERIATRICS
Use with Caution
ENDOXAN N 200MG INJECTION should be used with caution in elderly patients aged 65 years or above. Contact your doctor before receiving ENDOXAN N 200MG INJECTION.
OTHERS
ENDOXAN N 200MG INJECTION is not recommended for use if you have:
- acute infections
- bone-marrow aplasia
- urinary tract infection like cystitis
- acute urothelial toxicity from cytotoxic chemotherapy and radiation
- urinary outflow obstruction
- unmanageed infections
Before receiving ENDOXAN N 200MG INJECTION, inform your doctor if you have:
- bone marrow suppression
- serious infections include pneumonia, bacterial, fungal, viral, protozoal, and parasitic infections
- severe immune suppression
- concomitant chemotherapy and/or radiation therapy
- urinary tract and renal diseases like haemorrhagic cystitis, pyelitis, urethritis, and hematuria
- urotoxicity such as bladder ulceration, necrosis, fibrosis, contracture
- urinary tract obstructions or active urinary tract infections
- secondary malignancies (urinary tract cancer, myelodysplasia, acute leukemias, lymphomas, thyroid cancer, sarcomas, and bladder cancer)
- veno-occlusive liver disease
- poor wound healing
- hyponatremia
- SIADH (syndrome of inappropriate secretion of antidiuretic hormone)
- rare hereditary problems of fructose intolerance, galactose intolerance, glucose-galactose malabsorption
- diabetes
INTERACTIONS
A. Drug-Drug interactions:
Before receiving ENDOXAN N 200MG INJECTION, inform your doctor if you are taking any of the following medicine:
- Medicines used for cancer (Ex. paclitaxel, Busulfan, thiotepa)
- Depolarizing muscle relaxants Ex. succinylcholine (a medicine used in anaesthesia)
- Aprepitant
- Ciprofloxacin, chloramphenicol, sulfadiazine, sulfasalazine, sulfamethoxazole, Rifampin (medicines used to manage bacterial infections)
- Fluconazole, itraconazole, Amphotericin-B (medicines used for fungal infections)
- Prasugrel (medicines used to thin the blood)
- Allopurinol (medicines used for gout)
- Azathioprine (medicines used to reduce the activity of the immune system)
- Chloral hydrate (medicines used for insomnia)
- Medicines used to manage stomach ulcers (Ex. cimetidine)
- Disulfiram (medicines used for alcoholism)
- Glyceraldehyde (medicines used for warts)
- Protease inhibitors Ex. atazanavir, darunavir, Zidovudine (medicines used to manage viral infection)
- Ondansetron Â
- Medicines used to manage epilepsy or seizures (Ex. carbamazepine, phenobarbital, phenytoin)
- St. John’s wort (used for depression)
- Corticosteroids (medicines used for inflammation)
- Carbimazole (medicines used for an overactive thyroid)
- Medicines used for multiple sclerosis Ex. natalizumab
- Medicines used to manage high blood pressure (enalapril, thiazide diuretics such as hydrochlorothiazide or chlorthalidone)
- Amiodarone (medicines used to manage irregular heartbeat)
- Medicine used to increase white blood cell numbers after chemotherapy (Ex. GM-CSF, G-CSF)
- Indomethacin (medicines used to manage pain and inflammation)
- Etanercept (medicines used for rheumatoid arthritis)
- Metronidazole (medicines used for bacterial or protozoal infections)
- Bupropion (medicines used to manage depression)
- Digoxin, β-acetyl digoxin (medicines used for heart conditions)
- Vaccines Ex. BCG vaccine, anthrax vaccine (used to manage infections)
- Verapamil (medicines used to manage high blood pressure, angina or irregular heartbeat)
- Clozapine (medicines used to manage psychotic disorders)
Overdosage:
ENDOXAN N 200MG INJECTION will be administered by your doctor or nurse, so it is unlikely to cause an overdose, if you experience any unusual reactions, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | :Â Â | Cyclophosphamide |
| Pharmacological Category | :Â Â | Alkylating agents |
| Therapeutic Indication | :  | Malignant diseases, Minimal change nephrotic syndrome in children |
| Dosage Forms | :Â Â | Tablet, Injection, Infusion |
MORE INFORMATION
- Keep ENDOXAN N 200MG INJECTION out of the sight and reach from children
- Store ENDOXAN N 200MG INJECTION at 2°C to 8°C
| Weight | 25 g |
|---|
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