Azunate L 480mg Tablet 6’S C
- 8%

Azunate L 480mg Tablet 6’S C

Original price was: ₹146.00.Current price is: ₹135.00.

INTRODUCTION ABOUT AZUNATE L 480MG TABLET

AZUNATE
L 480MG TABLET is a combination of Artemether and Lumefantrine which
belongs to the group of medicines called Antimalarials. It is used in
infants, children and adults for the management of acute uncomplicated
malaria (mosquito borne disease with symptoms of fever with chills,
tiredness, nausea, vomiting, stomach pain) caused by a parasite called
plasmodium falciparum.  

AZUNATE L 480MG TABLET should be used
with caution in patients with severe liver or kidney problems or if the
patient feels worse or unwell to eat and drink.

AZUNATE L 480MG
TABLET is not recommended for use in patients having severe type of
malarial infection affecting the lungs, kidney or brain, heart condition
such as changes in the heart rhythm, slow heartbeat or severe heart
disease and low levels of electrolytes such as potassium or magnesium in
the blood.

AZUNATE L 480MG TABLET is generally not recommended
for use during the first trimester of pregnancy and it should be used
with caution during the second and third trimester of pregnancy and
breast-feeding women only if advised by the doctor.  

AZUNATE L
480MG TABLET should be used with caution in children and your child’s
doctor may adjust the dose depending upon child’s age and body weight.

The
most common side effects of taking AZUNATE L 480MG TABLET are headache,
dizziness, vomiting, stomach pain, nausea, muscle pain and loss of
appetite. Consult your doctor if any of the side effects worsen.

Azunate L 480mg Tablet 6'S C

Original price was: ₹146.00.Current price is: ₹135.00.

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SES OF AZUNATE L 480MG TABLET

  • Manage acute uncomplicated malarial infections (caused by plasmodium falciparum) in infants, children and adults

HOW AZUNATE L 480MG TABLET WORKS

AZUNATE L 480MG TABLET effectively manages malarial infections, where artemether
effectively kills the malarial parasites by binding to haem (part of
molecules that contains iron which is toxic to malarial parasites) which
is produced during the breakdown of haemoglobin. Lumefantrine works by
binding to hemin where it manages the formation of a toxic malarial
pigment called hemozoin, thereby it manages malarial infection. In
addition to this artemether and lumefantrine blocks nucleic acid and
protein synthesis in parasite that damages the parasitic cell membrane
of plasmodium falciparum which leads to the death of parasite. Thus, it
helps in managing the malarial infection.

DIRECTIONS FOR USE

Take AZUNATE L 480MG TABLET exactly as advised by your doctor.

For Tablet, Capsule: Swallow
AZUNATE L 480MG TABLET with a glass of water. This medicine should be
taken with food or drinks rich in fat such as milk. Crush the medicine
into powder if your child is unable to swallow the whole medicine.

For Dispersible Tablet: Disperse AZUNATE
L 480MG TABLET in the specified quantity of water as mentioned in the
label. Consume the mixture immediately after reconstitution.

Your
doctor will decide the correct dose and duration for you depending upon
your age, body weight and severity of the disease condition.

SIDE EFFECTS OF AZUNATE L 480MG TABLET

COMMON

  • headache, dizziness
  • nausea, vomiting
  • stomach pain
  • diarrhea
  • muscle or joint pain
  • difficulty to sleep
  • loss of appetite
  • cough
  • fast heartbeat
  • general weakness, tiredness
  • involuntary muscle spasms
  • abnormal walking (in children above 12 years)
  • tingling sensation or numbness of hand and feet
  • rashes or itching in the skin
  • disturbance in heart rhythm (prolonged QTc interval)

UNCOMMON

  • sleepiness
  • decreased skin sensitivity
  • inability to coordinate movements

RARE

  • allergic reactions

Stop taking AZUNATE L 480MG TABLET and contact your doctor immediately if you experience any of the following side effects:

  • swelling of the face, lips, tongue or throat with difficulty in breathing and swallowing
  • skin condition with large fluid filled blisters (bullous eruption)

HOW TO MANAGE SIDE EFFECTS

Headache:  

Rest
and relax. Drink plenty of fluids such as water or electrolytes. Apply a
pain-relieving balm on the forehead if required. Do not consume too
much of alcohol. Consult your doctor if the symptom does not improve.

Nausea and vomiting:

Stick
to simple meals while taking this medicine. Avoid eating oily, fried or
spicy foods. Do not lie down or sleep immediately after eating. Consult
your doctor if the symptom does not improve. 

Stomach pain:

Rest
and relax. Eat and drink slowly or try to have smaller and frequent
meals. Keep a heat pad on your stomach. Do not self-manage on your own
and consult your doctor if the symptom does not improve. 

Diarrhea:

Drink
lot of fluids such as water or fruit juices to keep yourself hydrated.
Avoid taking any medicine on your own for managing diarrhea. Consult
your doctor if the symptom does not improve.

Tiredness:

Drink
plenty of fluid and eat balanced diet and frequent meals. Do regular
minimal exercise and follow regular sleep schedule. Consult your doctor
if the symptom does not improve.

WARNING & PRECAUTIONS

PREGNANCY

AZUNATE
L 480MG TABLET is generally not recommended for use during the first
trimester of pregnancy. It should be used with caution during second and
third trimester of pregnancy only if considered clearly necessary.
Consult your doctor before taking AZUNATE L 480MG TABLET.

BREASTFEEDING

AZUNATE
L 480MG TABLET should be taken with caution in breast feeding women
only if considered clearly necessary. Consult your doctor before taking
AZUNATE L 480MG TABLET.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you experience dizziness, sleepiness or weakness after taking AZUNATE L 480MG TABLET.

KIDNEY

AZUNATE
L 480MG TABLET is not recommended for use in patients having severe
type of malarial infection affecting the kidneys. It should be taken
with caution in patients with severe kidney problems. Consult your
doctor before taking AZUNATE L 480MG TABLET.

LIVER

AZUNATE
L 480MG TABLET should be taken with caution in patients with severe
liver problems. Consult your doctor before taking AZUNATE L 480MG
TABLET.

ALLERGY

Do not take AZUNATE L 480MG TABLET if you are allergic to Artemether, Lumefantrine or any other ingredients of this medicine.

LUNGS

AZUNATE
L 480MG TABLET is not recommended for use in patients having malaria
with pulmonary edema or severe type of malarial infection affecting the
lungs. Consult your doctor before taking it.

HEART DISEASE

AZUNATE
L 480MG TABLET is not recommended for use in patients with severe heart
disease or with heart diseases such as slow heartbeat, changes in the
rhythm or rate of the heartbeat or family history of death due to heart
problems or born with heart problems. AZUNATE L 480MG TABLET should be
taken with caution in patients with variations in ECG (prolongation of
QTc interval). Consult doctor before taking AZUNATE L 480MG TABLET.

OTHERS

AZUNATE L 480MG TABLET is not recommended for use if you have:

  • severe type of malarial infection that has affected the brain
  • low levels of electrolytes such as potassium or magnesium in blood

Before taking AZUNATE L 480MG TABLET, inform your doctor if you:

  • infected with both the plasmodium falciparum and plasmodium vivax parasites
  • feeling worse or if you feel too unwell to eat and drink

Use in pediatrics

AZUNATE
L 480MG TABLET should be given with caution in children as the dosages
of AZUNATE L 480MG TABLET vary in children according to their body
weight. So, consult a paediatrician before you give this medicine to
your child.

Use in geriatrics

AZUNATE L 480MG TABLET can be used in elderly patients. However, consult your doctor before taking this medicine.

INTERACTIONS

A. Drug – drug interactions:

Before taking AZUNATE L 480MG TABLET, inform your doctor if you are taking any of the following medicines:

  • medicines used to manage heart rhythm problems (Ex. Flecainide, metoprolol)
  • medicines used to manage depression (Ex. imipramine, amitriptyline, clomipramine, St. John’s wort)
  • medicine used to manage leprosy or tuberculosis (Ex. rifampicin)
  • medicines
    used to manage bacterial infections (EX.  fluroquinolones such as
    ciprofloxacin, levofloxacin, macrolide antibiotics like azithromycin,
    erythromycin)
  • medicines used to manage fungal infection (Ex. ketoconazole, fluconazole, itraconazole)
  • medicines used to manage allergy (Ex. terfenadine, astemizole)
  • medicine used to manage stomach disturbance (Ex. cisapride)
  • medicines used to manage fits (Ex. carbamazepine, phenytoin)
  • medicines used to manage malaria (Ex.  atovaquone/proguanil, chloroquine)
  • medicines used to manage HIV infection (Ex. indinavir, ritonavir)
  • medicine used to manage pregnancy (Ex. Ethinyl estradiol)

B. Drug – Food interactions

Drink grapefruit juice with caution while taking AZUNATE L 480MG TABLET as it may interact with this medicine.

Overdosage:

If
you or anyone else accidentally take too much of AZUNATE L 480MG
TABLET, consult your doctor immediately or visit a nearby hospital.

SYNOPSIS

Drug :   Artemether, Lumefantrine
Pharmacological Category :   Antimalarials
Therapeutic Indication :   Manages acute uncomplicated malaria
Dosage Forms :   Tablet, Dispersible tablet, Injection, Syrup, Oral suspension, Dry Syrup

MORE INFORMATION

  • Keep AZUNATE L 480MG TABLET out of reach of children
  • Store AZUNATE L 480MG TABLET at room temperature

FAQs ABOUT AZUNATE L 480MG TABLET

What is AZUNATE L 480MG TABLET used for?

AZUNATE
L 480MG TABLET is used in infants, children and adults for the
management of acute uncomplicated malaria (mosquito born disease with
symptoms of fever with chills, tiredness, nausea, vomiting, stomach
pain) caused by a parasite called plasmodium falciparum.

Does AZUNATE L 480MG TABLET helps to manage malaria?

AZUNATE
L 480MG TABLET is not used to manage malaria. It is only used to manage
malarial infection caused by a parasite called plasmodium falciparum.
Consult your doctor for advice before taking this medicine.

Is AZUNATE L 480MG TABLET safe to use in pregnant women?

AZUNATE
L 480MG TABLET is generally not recommended for use during the first
trimester of pregnancy. It should be used with caution during second and
third trimester of pregnancy only if considered clearly necessary.
Consult your doctor before taking AZUNATE L 480MG TABLET.

Can AZUNATE L 480MG TABLET be used in patients with kidney problems?

AZUNATE
L 480MG TABLET is not recommended for use in patients having severe
type of malarial infection affecting the kidneys. It should be taken
with caution in patients with severe kidney problems. Consult your
doctor before taking AZUNATE L 480MG TABLET.

Does AZUNATE L 480MG TABLET cause diarrhea?

Yes,
AZUNATE L 480MG TABLET may cause diarrhea in some individuals. To
manage this effect, drink lot of fluids such as water or fruit juices to
keep yourself hydrated. Avoid taking any medicine on your own for
managing diarrhea. Consult your doctor if the symptom does not improve.

REFERENCES

1. KD Tripathi. Antimalarial drugs. Essentials of Medical Pharmacology. Eighth edition. 2019. Page: 875-77.

2.
Stephan Ehrhardt, Christian G Meyer. Artemether–lumefantrine in the
treatment of uncomplicated Plasmodium falciparum malaria. NIH. National
Library of medicine. National center for Biotechnology Information.
PubMed central. October 2009. [Accessed on 3rd November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762439/

3.
Novartis Pharmaceuticals. Pharmacokinetics, Safety, Tolerability and
Efficacy of a New Artemether-lumefantrine Dispersible Tablet in Infants
and Neonates <5 kg Body Weight With Acute Uncomplicated Plasmodium
Falciparum Malaria (CALINA). NIH U.S. National Library of Medicine
ClinicalTrials.gov. [Revised in March 2020] [Accessed on 3rd November
2022] https://clinicaltrials.gov/ct2/show/NCT04300309

4. Novartis Ireland Limited. Electronic Medicines Compendium (EMC). [Revised in August 2021] [Accessed on 3rd November 2022] https://www.medicines.org.uk/emc/files/pil.1628.pdf

5. Ajanta Pharma Ltd. Food and Drugs Authority (FDA).[Revised in February 2018] [Accessed on 3rd November 2022] https://fdaghana.gov.gh/img/smpc/Artefan%20(Artemether-Lumefantrine%2060mg-360mg)%20Tablets.pdf

6. Ajanta Pharma Ltd. Artefan 80/480 (Artemether and Lumefantrine). [Revised in March 2019] [Accessed on 3rd November 2022] https://extranet.who.int/pqweb/sites/default/files/MA130part3.pdf

7. Ajanta Pharma Ltd. Artefan 40/240 (Artemether and Lumefantrine). [Revised in March 2019] [Accessed on 3rd November 2022] https://extranet.who.int/pqweb/sites/default/files/MA128part3.pdf

8. Getz pharma ltd. Artheget (Artemether + Lumefantrine). [Accessed on 3rd November 2022] https://getzpharma.com/wp-content/uploads/2016/07/Artheget-Range-Leaflet-Pakistan.pdf

9. Cipla Ltd. Lumet 80 Tablets (Artemether + Lumefantrine). CiplaMed. [Revised in October 2013] [Accessed on 3rd November 2022] https://ciplamed.com/content/lumet-80-tablets

Weight 15 g

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