INTRODUCTION ABOUT ESIFLO 100 TRANSCAP
ESIFLO
100 TRANSCAP is a combination of Fluticasone and Salmeterol which
belongs to the group of medicines called Corticosteroids and
Bronchodilators respectively. It is used to manage asthma and chronic
obstructive pulmonary disease (COPD) in adults and in children (aged 4
years or above). It also helps in reducing the flare-ups of COPD
symptoms.
Use ESIFLO 100 TRANSCAP every day until your doctor
tells you to stop. It is meant for inhalation use only. Do not stop
using this medicine once your symptoms subside without consulting your
doctor.
ESIFLO 100 TRANSCAP should not be used to relieve a
sudden asthma attack (such as sudden breathing problems). Instead
contact your doctor or use a fast-acting ‘rescue’ inhaler to subside the
symptoms.
Before using ESIFLO 100 TRANSCAP inform your doctor if
you have any lung infections, liver problems or heart problems. You
must also inform your doctor if you have diabetes, hypertension, fits,
overactive thyroid functions, osteoporosis, adrenal gland problems or a
weak immune system as a precaution.
ESIFLO 100 TRANSCAP should be
used in pregnant or breastfeeding women only if it is considered
necessary by the physician. The most common side effects of using ESIFLO
100 TRANSCAP are headache, cold, oral thrush or oral sores, throat
irritation, hoarse voice, muscle pain and joint pain. Contact your
doctor if any of these side effect worsens.
USES OF ESIFLO 100 TRANSCAP
It is used in adults and in children (aged 4 years or above) to manage, manage the symptoms of:
- Asthma
- Chronic Obstructive Pulmonary Disease (COPD)
HOW ESIFLO 100 TRANSCAP WORKS
ESIFLO
100 TRANSCAP is a combination of two medicines namely, fluticasone and
salbutamol. Fluticasone is an inhalation corticosteroid. It blocks the
release of certain chemical messengers in the airways (such as
prostaglandins, leukotrienes) that cause inflammation and swelling.
Salmeterol
is a bronchodilator. It relaxes the smooth muscles of the airways and
widens them. Collectively, they reduce airway inflammation, allows the
air to pass through more freely and makes breathing easier.
DIRECTIONS FOR USE
Use
ESIFLO 100 TRANSCAP every day until your doctor tells you to stop. It
is meant for inhalation use only. Inhale the medicine only through your
mouth into the lungs and not via nose.
Closely follow the instructions given by your doctor regarding the number of inhalations and dosing intervals.
- Insert
the capsule into the capsule chamber or into the hole present in the
inhalation device and pierce it my adjusting the device - Place
the mouthpiece of the device between your teeth and close your mouth
tightly. Breath in through your mouth deeply and rapidly - Hold
your breath for 10 seconds or for as long as is comfortable and then
breathe out normally. Repeat the same steps for further inhalations as
well
Once inhalation is over, rinse your mouth with water and spit it out or brush your teeth.
Do
not start using this medicine unless your doctor or health care
provider has taught you how to use and you understand how to use it
correctly.
SIDE EFFECTS OF ESIFLO 100 TRANSCAP
COMMON
- headache
- common cold
- thrush in the mouth or throat (a yeast infection that causes sore, creamy-yellow, raised patches)
- sore tongue, hoarse voice, throat irritation
- muscle pain or cramps
- joint pain and swelling
- bruising and fractures
- inflammation of sinuses
- signs of low levels of potassium in blood (such as an uneven heartbeat, muscle weakness or cramps)
UNCOMMON
- diabetes (increased blood sugar levels)
- cataract (cloudy eyes)
- unusually fast or uneven heartbeat, tremor (feeling shaky)
- chest pain
- feeling worried, disturbance in sleep
- allergic skin rash
RARE
- slowing of growth in adolescents, bone thinning, glaucoma, weight gain
- Cushing’s Syndrome (a disorder caused due to release of high levels of cortisol)
- changes in behavior (such as being unusually active and irritable)
- fungal infection in the esophagus which causes difficulties in swallowing
Stop using ESIFLO 100 TRANSCAP and contact your doctor immediately if you experience any of the following side effects:
- severe
allergic reactions (such as sudden wheezing, cough, shortness of
breath, skin rash, itching, swelling of the face, lips, tongue, or
throat, breathing difficulties, sudden fast heartbeat which can cause
fainting, light-headedness, collapse or even loss of consciousness) - sign
of pneumonia (a lung infection accompanied with fever, chills,
increased cough production, increased breathing difficulties, excessive
mucus production and change in mucus color)
HOW TO MANAGE SIDE EFFECTS
Headache:
Rest
and relax. Drink plenty of fluids such as water or electrolytes. Apply a
pain-relieving balm on the head if required. Do not consume too much of
alcohol. Consult your doctor if the symptom did not improve.
Throat irritation:
Gargle
your throat with salt water twice a day. Always try to drink warm
water. Avoid chilled, cooled, or sweetened food items or beverages.
Drinking turmeric milk or ginger tea mixed with honey and pepper powder
can ease the soreness. Consult your doctor if the symptom did not
improve.
Muscle pain or cramps:
Rub a
pain-relieving balm or place a heat pack on the affected area for some
time, as it could ease the pain. Do not move the affected area
frequently. Try to do some simple movements every day which would
improve blood circulation and reduce further incidence of muscle pain.
Try to eat a well-balanced protein rich diet, so that it can help to
repair and rebuild the damaged muscle. Consult your doctor if the
symptom did not improve.
Joint pain:
Rub a
pain-relieving balm or place a heat pack on the affected area for some
time, as it could ease the pain. Do not move the affected area
frequently. Consume calcium and vitamin supplements regularly,
particularly if you are elderly. Consult your doctor if the symptom did
not improve.
Allergic skin rash:
Avoid
hot showers because hot water can irritate your skin further. Do not
scratch the affected area. Use protective clothing when going outdoors.
Regularly moisturize your skin. Consult your doctor if the symptom did
not improve.
WARNING & PRECAUTIONS
PREGNANCY
ESIFLO
100 TRANSCAP should be used in pregnant women only if it is considered
necessary by the doctor. Your doctor may prescribe this medicine after
outweighing the risk and benefits to you and your baby. Therefore,
inform your doctor before using it.
BREASTFEEDING
ESIFLO
100 TRANSCAP should be used in breastfeeding women only if it is
considered necessary by the doctor. Therefore, consult your doctor for
advice before using it.
DRIVING AND USING MACHINES
Do not drive or operate any heavy tools or machines if your ability is affected by ESIFLO 100 TRANSCAP.
LIVER
ESIFLO
100 TRANSCAP should be taken with caution in patients with liver
diseases. Therefore, consult your doctor before using it.
ALLERGY
Do not use ESIFLO 100 TRANSCAP if you are allergic to Salmeterol or Fluticasone.
LUNGS
ESIFLO
100 TRANSCAP should be taken with caution among patients who have or
previously had tuberculosis or any other lung infections. Therefore,
consult your doctor before using it.
HEART DISEASE
ESIFLO
100 TRANSCAP should be taken with caution in patients with heart
diseases (such as irregular or fast heartbeat). Therefore, consult your
doctor before using it.
OTHERS
ESIFLO 100 TRANSCAP is not recommended for use in patients having:
- status asthmaticus (respiratory failure)
- acute asthma attacks
Before using ESIFLO 100 TRANSCAP, inform your physician if you:
- have an over-active thyroid gland
- have diabetes
- have high blood pressure
- have hypokalemia (low levels of potassium in blood)
- have fits (seizure)
- have osteoporosis (weak bones)
- have a weak immune system
- have or had eye problems (such as glaucoma, increased pressure in the eyes, cataracts)
- have viral, bacterial or fungal infections (Ex. measles, chickenpox)
- have glucose intolerance
- have problems in adrenal gland (Ex. adrenal insufficiency)
- met with any major trauma (accidents) or undergone a surgery
Use in pediatrics:
ESIFLO
100 TRANSCAP is not recommended for use in children younger than 4
years of age. Kindly consult your doctor before using it.
Use in geriatrics:
ESIFLO
100 TRANSCAP should be taken with caution in elderly patients (aged 65
years or above). Therefore, consult your doctor before using it. Proper
dose adjustments and careful monitoring are required in such patients.
INTERACTIONS
A. Drug-Drug interactions:
Before using ESIFLO 100 TRANSCAP, inform your physician if you are taking any of the following medicines such as:
- other beta-blockers (used to manage high blood pressure or other heart conditions) Ex. atenolol, propranolol and sotalol
- medicines used to manage fungal infection (such as ketoconazole and itraconazole)
- medicines used to manage HIV infection (Ex. ritonavir, atazanavir, indinavir, nelfinavir, saquinavir or cobicistat)
- clarithromycin, erythromycin (used to manage bacterial infections)
- other corticosteroids (taken orally or via injections to manage pain or inflammation) Ex. dexamethasone
- potassium-sparging diuretics (used to manage high blood pressure by increasing urine output) Ex. spironolactone, acetazolamide
- other medicines that can cause bronchodilation (such as salbutamol, formoterol)
- xanthine medicines (used to manage asthma) Ex. theophylline and aminophylline
- nefazodone (used to manage depression)
- medicines
used to manage depression such as (rasagiline, selegiline, phenelzine,
amitriptyline, nortriptyline, doxepin, imipramine, desipramine)
Overdosage:
If
you or anyone else accidentally inhaled excessive amount of this
medicine, contact your doctor immediately or go to the hospital straight
away. Symptoms of overdosage might include shortness of breath, chest
pain, fast heartbeat, feeling shaky, dizziness, headache, muscle
weakness and joint pain.
SYNOPSIS
| Drug | :Â Â | Fluticasone, Salmeterol |
| Pharmacological Category | :Â Â | Corticosteroids, Beta-1 receptor agonists |
| Therapeutic Indication | :Â Â | Asthma, COPDÂ Â Â Â Â Â |
| Dosage Forms | :Â Â | Autohaler, Blisters, Capsule, Inhalation capsule,Octacaps, Respicaps, Rotacaps, Trans caps, Nexcaps,Accuhaler, Inhaler, Ciphaler, Multihaler |
MORE INFORMATION
- Keep ESIFLO 100 TRANSCAP out of reach of children
- Store ESIFLO 100 TRANSCAP at room temperature
FAQs ABOUT ESIFLO 100 TRANSCAP
What is the use of ESIFLO 100 TRANSCAP?
ESIFLO
100 TRANSCAP is used to manage asthma and chronic obstructive pulmonary
disease (COPD) in adults and in children (aged 4 years or above). It
also helps in reducing flare-ups of COPD symptoms.
How ESIFLO 100 TRANSCAP works in my body?
ESIFLO
100 TRANSCAP relaxes the smooth muscles of the airways and widens them.
It also reduces the inflammation of airway tract. Therefore, it allows
the air to pass through more freely and makes breathing easier.
Can ESIFLO 100 TRANSCAP be used on an asthma attack?
ESIFLO
100 TRANSCAP is only used to manage or manage the symptoms of asthma
and COPD (such as breathlessness or wheezing). If your asthma or
breathing gets worse suddenly, contact your doctor immediately or go to
the straight away to avoid further exacerbation of the attack. Meanwhile
use a fast-acting rescue inhaler containing salbutamol along with this
medicine.
Is ESIFLO 100 TRANSCAP safe?
ESIFLO 100 TRANSCAP is considered safe at doses prescribed by the physician.
What are the side effects of using ESIFLO 100 TRANSCAP?
The
most common side effects of using ESIFLO 100 TRANSCAP are headache,
cold, oral thrush or oral sores, throat irritation, hoarse voice, muscle
pain and joint pain. Contact your doctor if any of these side effect
worsens.
Can I stop using ESIFLO 100 TRANSCAP once my symptoms subside?
No.
Use ESIFLO 100 TRANSCAP every day until your doctor tells you to stop.
Do not stop using this medicine abruptly or reduce the dose without
consulting your doctor, as it could make your breathing even worse. Your
doctor will access your disease condition regularly and will increase
or decrease the dose accordingly.
Will ESIFLO 100 TRANSCAP more effective if taken at higher doses?
Always
consume the dose prescribed for you by your physician. Your doctor will
decide the correct dose and duration of therapy for you depending upon
your age, body weight and severity of the disease. Do not take a higher
dose of this medicine without consulting your doctor as it could lead to
unwanted side effects. It your symptoms are not relieved by the
prescribed dose, consult your doctor so that he might adjust the dose
according to your health condition or can suggest an alternative
therapy.
I’m pregnant. Can I use ESIFLO 100 TRANSCAP?
ESIFLO
100 TRANSCAP should be used in pregnant women only if it is considered
necessary by the physician. Your doctor will prescribe you with ESIFLO
100 TRANSCAP after evaluating the risks and benefits of the therapy.
Can ESIFLO 100 TRANSCAP be used in children?
ESIFLO
100 TRANSCAP is considered safe for use in children (aged 4 years or
above). However, it is not recommended for use in children younger than 4
years due to lack of safety data. Kindly consult your doctor before
taking.
How long will it take for ESIFLO 100 TRANSCAP to relieve the symptoms and how long the effects can last?
Generally,
ESIFLO 100 TRANSCAP takes about 10-15 minutes to relieve the symptoms
of asthma or COPD. However, the onset of action slightly differs from
person to person based upon their disease condition. The effects of
ESIFLO 100 TRANSCAP can last for 12-18 hours, because salmeterol present
in this medicine is considered as a longer-acting beta-1 adrenergic
agonist.
Can ESIFLO 100 TRANSCAP cause infection in the mouth?
Yes.
ESIFLO 100 TRANSCAP may cause fungal infections of the mouth (oral
thrush). To avoid this, make sure to rinse your mouth with water after
inhaling the medicine. However, if an infection develops, consult your
doctor.
What happens when you forget to use ESIFLO 100 TRANSCAP?
If
you forget to use ESIFLO 100 TRANSCAP, use it as soon as you remember.
However, if it’s time for the next dose, skip the missed dose and take
the next dose. Do not use a double dose to compensate the missed dose.
Can ESIFLO 100 TRANSCAP be used if you have an infection?
Inform
your doctor if you have any bacterial, fungal, or viral infection
before using ESIFLO 100 TRANSCAP. Your doctor will evaluate your
existing health condition and advise changes in management accordingly.
Also, inform your doctor if have exposure to an infectious environment
or with a person with infectious diseases, as ESIFLO 100 TRANSCAP may
mask your symptoms of the infection.
REFERENCES
1.
KD. Tripathi. Drugs for Cough and Bronchial Asthma. Essentials of
medical pharmacology. Seventh edition. 2013. Page – 221-224 &
230-233.
2. Monika Gappa, Wolfgang Zachgo, Andrea von
Berg, Wolfgang Kamin, Catrin Stern-Sträter, Gratiana Steinkamp, VIAPAED
Study Group. Add-on salmeterol compared to double dose fluticasone in
pediatric asthma: a double-blind, randomized trial (VIAPAED). NIH
National Library of Medicine, National center for biotechnology
information. Pubmed.gov. November 2009. [Accessed on 16th November
2022]Â https://pubmed.ncbi.nlm.nih.gov/19824054/
3. Stephen
J Fowler, Graeme P Currie, Brian J Lipworth. Step-down therapy with
low-dose fluticasone-salmeterol combination or medium-dose
hydrofluoroalkane 134a-beclomethasone alone. NIH National Library of
Medicine, National center for biotechnology information. Pubmed.gov.
June 2002. [Accessed on 16th November 2022]Â https://pubmed.ncbi.nlm.nih.gov/12063520/
4. G
P Currie, N J Syme-Grant, L C McFarlane, F A Carey, B J Lipworth.
Effects of low dose fluticasone/salmeterol combination on surrogate
inflammatory markers in moderate persistent asthma. NIH National Library
of Medicine, National center for biotechnology information. Pubmed.gov.
July 2003. [Accessed on 16th November 2022]Â https://pubmed.ncbi.nlm.nih.gov/12823118/
5. Rashmi
Mehta, Kylie Riddell, Ashutosh Gupta, Margaret Louey. Comparison of the
Pharmacokinetics of Salmeterol and Fluticasone Propionate 50/100 µg
Delivered in Combination as a Dry Powder Via a Capsule-Based Inhaler and
a Multi-Dose Inhaler. ScienceDirect. March 2015. [Accessed on 16th
November 2022]Â https://www.researchgate.net/publication/274089299_Comparison_of_the_Pharmacokinetics_of_Salmeterol_and_Fluticasone_Propionate_50100_g_Delivered_in_Combination_as_a_Dry_Powder_Via_a_Capsule-Based_Inhaler_and_a_Multi-Dose_Inhaler
6. Xiaofen
Jin, Lianfang Wu, Ji Wang, and Malong Feng. The comparison of
fluticasone propionate/formoterol with fluticasone propionate/salmeterol
for paediatric asthma: a meta-analysis of randomized controlled trials.
NCBI; PMC US National Library of Medicine, National Institute of
Health. June 2021. [Accessed on 16th November 2022]Â https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330866/
7. Glaxo Wellcome Production. Electronic Medicines Compendium (EMC). [Revised in March 2020] [Accessed on 16th November 2022]Â https://www.medicines.org.uk/emc/files/pil.5504.pdf
8.
Cipla Ltd. SEROFLO Rotacaps (Salmeterol + Fluticasone propionate).
Ciplamed.com. [Revised in August 2020]. [Accessed on 16th November
2022]Â https://www.ciplamed.com/content/seroflo-rotacaps
9.
Cipla Ltd. SEROFLO Inhaler (Salmeterol + Fluticasone propionate).
Ciplamed.com. [Revised in March 2020]. [Accessed on 16th November 2022]Â https://www.ciplamed.com/content/seroflo-inhaler
10. GlaxoSmithKline. U.S. Food & Drug Administration. [Accessed on 16th November 2022]Â https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021077s042lbl.pdf
| Weight | 40 g |
|---|
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