- 5%
Fungisome 25mg Injection 25ml
Original price was: ₹395.00.₹375.00Current price is: ₹375.00.
NTRODUCTION
FUNGISOME 25MG contains Amphotericin B which
belongs to the group of medicines called Anti-fungals. It is used in the
management of serious infections caused by fungi or yeasts and
leishmaniasis (parasitic diseases). Fungal infection is a disease caused
by fungus that enters the skin, spreads into tissue, bones or other
parts of the body and it is characterized by symptoms such as rash,
itching, skin darkening, and loss of skin colour.
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USES OF FUNGISOME 25MG
Manages:
- serious infections caused by fungi
- visceral leishmaniasis
HOW FUNGISOME 25MG WORKS
FUNGISOME
25MG effectively heals fungal infections by acting either as a
fungicidal (destroys the fungi) or fungistatic (stops the growth of
fungi). It acts by attaching itself to the fungal hormone (ergosterol)
which causes breakdown resulting in fungal cell death.
DIRECTIONS FOR USE
FUNGISOME
25MG will be given to you only by a doctor or a nurse into a vein as an
intravenous infusion. Your doctor will decide the correct dose and
duration for you depending upon your age, body weight and disease
condition.
SIDE EFFECTS OF FUNGISOME 25MG
COMMON
- reduced count of red blood cells (anemia)
- feeling tired, confused
- muscle weakness or cramps
- nausea
- vomiting
- fever, chills and shivering
- faster heart rate
- breathing difficulties
- low blood pressure (headache, dizziness)
- diarrhea
- skin rash
- abdominal pain
- decreased appetite
- chest and back pain
- pain at the site of injection (swollen veins, blood clot may be present)
- abnormal urine production (increased frequency), kidney stones
UNCOMMON
- irregular heartbeat
- numbness
- shortness of breath (spasm of lungs)
- yellowing of the eyes and skin
- muscular pain
- flushing
- severe allergic reaction (anaphylaxis)
- seizures, fits (convulsions)
- difficulty in breathing associated with wheezing
- bleeding for a long time after an injury, bleeding into skin, bruising
RARE
- blood clotting problems
- confusion, memory loss, disorientation, loss of alertness
- blurred or double vision
- loss of hearing, sensation of ringing in the ears (tinnitus)
- spinning sensation, off balance (vertigo)
- heart attack (acute chest pain, sweating, fainting) or heart not working properly
- high blood pressure
- shock (rapid, shallow breathing, cold skin, weak pulse, dizziness, fainting)
- inflammation and fluid in the lungs
- stomach cramps, indigestion
- intestinal bleed (black stool)
- loss of liver function
- itching
- flu like symptoms
- skin
conditions (skin coming off in layers, painful red or purple spreading
rash, a flat red area on the skin that is covered with small bumps) - joint pain
- loss of weight
Inform your doctor immediately if you experience any of the following side effects:
- swelling of the lips, face and tongue
- skin reactions (severe rash and itching)
- difficulty in breathing
- fever, chills, sore throat, ulcers in mouth or throat
- unusual bleeding or bruises
- increased thirst
- increased frequency and volume of urine
HOW TO MANAGE SIDE EFFECTS
Diarrhoea:
Drink
lots of fluids, such as water or fruit juice to keep yourself hydrated.
If the symptom does not improve consult your doctor.
Stomach pain:
Try
to rest and relax. Eat and drink slow or try to have smaller and
frequent meals. Keep a heat pad on your stomach. If the symptom does not
improve, contact your doctor.
Decreased appetite:
Eat
when you feel hungry. Eat smaller meals frequently than usual. Snack
only when you’re hungry. Eat a nutritious snack which is rich in
calories and protein, such as dried fruit and nuts. Consult your doctor
if the symptom does not improve.
Tiredness:
Drink
plenty of fluid and eat balanced diet and frequent meals. Follow
regular sleep schedule. Consult your doctor if the symptom does not
improve.
WARNING & PRECAUTIONS
PREGNANCY
FUNGISOME 25MG should be received with caution in pregnant women. Consult your doctor before receiving it.
BREASTFEEDING
FUNGISOME 25MG should be received with caution in breastfeeding women. Consult your doctor before receiving it.
DRIVING AND USING MACHINES
FUNGISOME 25MG should not affect your ability to drive. Consult your doctor before receiving it.
KIDNEY
FUNGISOME
25MG should be received with caution in patients with kidney disease
such kidney failure and are having dialysis. Consult your doctor before
receiving it.
LIVER
FUNGISOME 25MG should be received with caution in patients with liver disease. Consult your doctor before receiving it.
ALLERGY
Tell your doctor before receiving FUNGISOME 25MG if you are allergic to Amphotericin B.
OTHERS
FUNGISOME 25MG is not recommended for use if you:
- have diabetes
- have low potassium levels
Before receiving FUNGISOME 25MG, inform your doctor if you:
- have low potassium levels
- have a white blood cell transfusion
Use in pediatrics:
FUNGISOME 25MG is generally not recommended for use in babies below 1 month of age. Consult your doctor before receiving it.
INTERACTIONS
A. Drug – Drug interactions:
Before receiving FUNGISOME 25MG, inform your doctor if you are taking any of the following medicine:
- methotrexate, cyclophosphamide, cisplatin (used in management of cancer)
- gentamicin, vancomycin (used in management of bacterial infections)
- baclofen, dantrolene, diazepam (used to relax muscles)
- corticosteroids (used as anti-inflammatory medicine) Ex. beclomethasone, prednisolone
- digoxin (used to manage heart failure)
- flucytosine (used to manage fungal infections)
- pentamidine (used to manage pneumonia in people with AIDS and leishmaniasis)
- medicines used to supress the immune system (Ex. ciclosporin, tacrolimus)
- medicines that increase the amount of urine your body produces (Ex. furosemide)
- medicines used to control the amount of corticosteroids produced by body (Ex. corticotropin)
Overdosage:
FUNGISOME
25MG will be administered to you only by a doctor or a nurse in a
hospital, and so it is unlikely to receive an overdose. However, consult
your doctor or nurse if you experience any unusual symptoms.
SYNOPSIS
| Drug | :Â Â |
Amphotericin B |
| Pharmacological Category | :Â Â |
Anti-fungal |
| Therapeutic Indication | :Â Â |
Fungal infections |
| Dosage Forms | :Â Â |
Injection, Infusion, Emulsion, Gel |
MORE INFORMATION
- Keep FUNGISOME 25MG out of reach of children
- Store in a refrigerator 2-8°C
FAQs ABOUT FUNGISOME 25MG
Is FUNGISOME 25MG safe to use in patients with kidney disease?
FUNGISOME
25MG should be used with caution in patients with kidney disease such
as kidney failure and those who are undergoing dialysis. Consult your
doctor before receiving this medicine.
Is a test dose of FUNGISOME 25MG required?
Yes.
Your doctor might give you a test dose of FUNGISOME 25MG to check if
you are allergic to the medicine. Before receiving this medicine inform
your doctor about previous medication allergies.
Is FUNGISOME 25MG the drug of choice for manageing potentially life-threatening fungal diseases?
Yes.
FUNGISOME 25MG is the most effective drug and it is a gold standard of
antifungal therapy to manage serious and life-threatening fungal
infections. Your doctor might manage you with other drugs depending upon
your condition.
What precautions should I follow while being manageed with FUNGISOME 25MG?
Patients
receiving FUNGISOME 25MG should inform their doctor about their
pre-existing disease condition affecting kidney and liver or if you have
undergone white blood cell transfusion. Also, FUNGISOME 25MG contains
sugar, so patients with diabetes must tell their doctor. Consult your
doctor immediately if you experience any unusual symptoms.
Can FUNGISOME 25MG cause anaemia?
Yes.
FUNGISOME 25MG can cause anaemia by supressing the erythropoietin
production. However, these levels- may remain low during the management
and get back to normal after the management course.
What is FUNGISOME 25MG used for?
FUNGISOME
25MG belongs to a class of medications called antifungals which is used
to manage serious infections caused by yeasts and certain fungi which
works by slowing or killing the growth of fungi.
Is FUNGISOME 25MG an antibiotic or antifungal?
FUNGISOME
25MG is an antifungal medicine which acts as either a fungistatic
(stops the growth of fungi) or fungicidal (destroys the fungi) medicine
by binding to certain fungal hormone (ergosterol) that results in fungi
cell death.
What are the major side effects of FUNGISOME 25MG?
The
most common side-effects of using FUNGISOME 25MG are fever, chills or
shivering, tiredness, confusion, nausea, vomiting, difficulty in
breathing, low blood pressure, skin rash, headache. Its major side
effect is nephrotoxicity (impaired kidney function) which occurs by
various mechanisms.
How do you administer FUNGISOME 25MG?
FUNGISOME
25MG will be given to you only by a doctor or a nurse into a vein as an
intravenous infusion. Your doctor will decide the correct dose and
duration for you depending upon your age, body weight and disease
condition.
Can FUNGISOME 25MGbe given at home?
No.
FUNGISOME 25MG is used to manage invasive fungal infections which is
generally associated with significant adverse reactions particularly
nephrotoxicity (impaired kidney function) which makes it difficult to be
administered at home as infusion therapy.
REFERENCES
1. KD. Tripathi. Anti-Fungal Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 788, 789.
2. A
C Lin, E Goldwasser, E M Bernard, S W Chapman. Amphotericin B blunts
erythropoietin response to anemia. NIH National Library of Medicine,
National center for biotechnology information. Pubmed.gov. February
1990. [Accessed on 20th June 2022]Â https://pubmed.ncbi.nlm.nih.gov/2299214/
3.
Asif Noor; Charles V. Preuss. Amphotericin B. NIH National Library of
Medicine, National center for biotechnology information. [Revised in May
2022] [Accessed on 20th June 2022]Â https://www.ncbi.nlm.nih.gov/books/NBK482327/
4. Delpharm Saint Remy. Electronic Medicines Compendium (EMC). [Revised in September 2021] [Accessed on 20th June 2022]Â https://www.medicines.org.uk/emc/files/pil.10716.pdf
5. Gilead Sciences Ireland UC. Electronic Medicines Compendium (EMC). [Revised in September 2020] [Accessed on 20th June 2022]Â https://www.medicines.org.uk/emc/files/pil.1022.pdf
| Weight | 15 g |
|---|
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