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MESACOL CR Granules 1gm
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Introduction About MESACOL CR GRANULES
What is Mesacol CR Granules 1gm?
MESACOL CR Granules 1gm contains Mesalamine, an anti-inflammatory drug used to manage mild to moderate ulcerative colitis.
MESACOL CR Granules 1gm helps in reducing inflammation in the colon, effective in maintaining remission in ulcerative colitis and slow-release formula for prolonged action.
Follow your doctor’s instructions for dosage and duration. Typically, MESACOL CR Granules is taken with or without food.
Before taking MESACOL CR Granules 1gm, inform your doctor if you suffer from an active peptic ulcer, and/or have lung problems (asthma), mild to moderate kidney or liver problems.
MESACOL CR Granules 1gm should be used with caution in pregnant and breastfeeding women only if it is clearly necessary.
The most common side effects of MESACOL CR Granules 1gm are nausea and vomiting, abdominal pain, diarrhea or headache. Consult your doctor if any of these above side effects worsens or persists for a longer duration.
Uses Of MESACOL CR GRANULES
- Used to manage mild to moderate Ulcerative colitis
Benefits of MESACOL CR GRANULES
1. Helps in reducing inflammation in the colon:Â
- MESACOL CR Granules contain Mesalazine (5-Aminosalicylic Acid), which has anti-inflammatory properties that help reduce inflammation in the lining of the colon
- It works by blocking the production of inflammatory chemicals (prostaglandins and leukotrienes), providing relief from symptoms like abdominal pain, diarrhea, and rectal bleeding
2. Effective in maintaining remission in ulcerative colitis:
- This medication is commonly prescribed for patients with ulcerative colitis, a chronic inflammatory bowel disease (IBD)
- It helps in managing flare-ups and maintaining long-term remission, reducing the frequency of relapses
3. Slow-release formula for prolonged action:
- The controlled-release (CR) formulation ensures gradual and sustained release of Mesalazine throughout the colon
- This helps maintain consistent therapeutic levels in the body, providing long-lasting relief and reducing the need for frequent dosing
How MESACOL CR GRANULES Works
Mechanism of action:Â Learning how MESACOL CR Granules 1gm works to reduce inflammation in the intestines
1. Targeted delivery to the colon:
- MESACOL CR (controlled release) formulation ensures that Mesalazine is gradually released in the colon rather than the stomach
- This slow-release mechanism maximizes its anti-inflammatory effects exactly where it is needed
2. Inhibition of inflammatory pathways:
- Mesalazine works by blocking the cyclooxygenase (COX) and lipoxygenase (LOX) pathways, reducing the production of inflammatory mediators like Prostaglandins and Leukotrienes
3. Reduction of oxidative stress:
- It neutralizes free radicals that contribute to inflammation and tissue damage in the intestines
- This helps protect the intestinal lining from further damage
4. Modulation of the immune response:
- MESACOL CR Granules suppress excessive immune activity, reducing immune cells from attacking the intestinal lining
- This reduces swelling, pain, and ulcer formation, helping maintain remission in ulcerative colitis
Onset of action: When will it start working? Initial Improvement
- Some patients may notice symptom relief within a few days (especially reduced diarrhea and cramping)
- For others: It may take 2-4 weeks to feel significant improvement
Full effectiveness:
- For acute flare-ups:Â It may take 4-8 weeks for full symptom control
- For maintenance therapy:Â Continuous use helps to reduce relapses and keep ulcerative colitis in remission
Expected management outcomes:
1. Short-term benefits (first few weeks):
- Reduction in diarrhea, rectal bleeding, and urgency
- Decreased abdominal pain and cramping
2. Long-term benefits (after continued use):
- Management of Flare-Ups:Â Regular use helps maintain long-term remission
- Healing of the Intestinal Lining:Â Over time, inflammation reduces, promoting gut healing
- Improved quality of life:Â Patients experience fewer disruptions from bowel-related symptoms
How to use MESACOL CR GRANULES
MESACOL CR Granules is a prescription medicine which needs to be taken under medical supervision. Always consult your doctor or pharmacist if you have any questions or concerns about taking this medication.
How to take MESACOL CR Granules 1gm
- Follow your doctor’s instructions for dosage and duration
- Typically MESACOL CR Granules 1gm is taken with or without food
Dosage Instructions:
1. For mild to moderate Ulcerative Colitis (Adults):
- Induction of Remission (Active Disease):Â 1-2g once daily or in divided doses
- Maintenance of Remission:Â 1g once daily
2. For pediatric use (children above 6 years):
- Dose is weight-based: Consult a doctor for exact dosage
Administration Methods: Step-by-step guidance on how to take the granules, such as mixing with water or food, and whether to consume with meals
Option 1:Â Direct Consumption (Recommended method)
- Open the Sachet:Â Tear the sachet carefully to avoid spilling the granules
- Place granules on the tongue:Â Empty the entire contents directly onto your tongue
- Swallow immediately:Â Wash it down with a full glass of water or orange juice
- Do not chew or crush the granules, as this may interfere with the slow-release mechanism
Option 2:Â Mixing with Food or Liquid (Alternative method)
- Mix with soft food:Â You can sprinkle the granules over a small amount of yogurt, applesauce, or pudding
- Stir gently and consume immediately without chewing
- Mix with water or juice:Â Add the granules to a glass of water or orange juice. Stir well and drink the mixture immediately
- Do not store the mixture for later use
What if I forgot to take MESACOL CR GRANULES
- Take the missed dose as soon as you remember, if it has only been a few hours, take the missed dose immediately
- Swallow the granules with water, juice, or yogurt as directed
- Skip the missed dose if it is almost time for the next dose
- If your next scheduled dose is within a few hours, skip the missed dose and take the next one at your usual time
- Do not take two doses at once to make up for the missed one
- Do not chew the granules – Always swallow them whole as directed
Overdose
If you or anyone else accidentally takes too much of MESACOL CR Granules 1gm, consult your doctor immediately or visit the nearby hospital to manage the overdose symptoms.
Side Effects Of MESACOL CR GRANULES
Common:
- nausea and vomiting
- abdominal pain
- diarrhea
- headache
When to consult a doctor?
- serious skin reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis associated with symptoms such as reddish non-elevated, target-like/circular patches on the trunk associated with central blisters, skin peeling, ulcers of eyes, nose, mouth, throat and/or genitals
- signs of severe allergic reaction such as severe skin rashes, difficulty in breathing/swallowing, swelling of the face/neck
- suddenly developed abdominal cramps/pain, fever, severe headache and/or rash
How To Manage Side Effects
Diarrhea
- Drink plenty of water and stay hydrated
- Try to avoid taking any medicine on your own to manage diarrhea
- Consult and inform your doctor if the symptom worsens.
Headache
- If MESACOL CR Granules 1gm causes headache, take rest and drink plenty of fluids
- Ask your doctor to recommend a painkiller
- Headaches should usually go away after the first week of using MESACOL CR GRANULES if it lasts more than a week or severe, inform your doctor
Nausea And Vomiting
- Take MESACOL CR Granules 1gm with or just after a meal
- Stick to simple meals
- Avoid eating oil rich or spicy foods, sugary snacks and drinks
- Avoid drinking too much liquid along with your meals, drink slowly in between meals
Stomach Pain
- If MESACOL CR is causing stomach irritation, try taking it with meals to reduce irritation of the stomach lining
- Staying well-hydrated can help reduce cramping and discomfort
- Apply a warm compress:Â placing a hot water bottle on the abdomen can help ease cramps
Warning & Precautions
Pregnancy
Consult your doctor
MESACOL CR Granules 1gm can be used during pregnancy if the benefits outweigh potential risks. Studies suggest no major congenital disabilities associated with mesalazine.
Breastfeeding
Safe
Small amounts pass into breast milk, MESACOL CR Granules 1gm generally considered safe for nursing mothers. There is no major effects on infants reported, most babies tolerate it well.
Driving and Using Machines
Use with Caution
MESACOL CR Granules 1gm is unlikely to affect your ability to drive or operate machines.
Alcohol
Consult your doctor
Consult and inform your doctor if you are planning to consume alcohol while taking MESACOL CR Granules 1gm.
Kidney
Use with Caution
MESACOL CR Granules 1gm should be used with caution in patients with kidney disease. Because mesalazine is eliminated through the kidneys, and impaired kidney function can lead to drug accumulation. Kidney function tests (creatinine clearance, eGFR) should be monitored regularly. If you have chronic kidney disease (CKD), discuss dose adjustments with your doctor. Avoid use in severe renal failure unless prescribed by your doctor.
Liver
Use with Caution
MESACOL CR Granules 1gm should be used with caution in patients with liver disease. Liver enzymes help metabolize mesalazine, and liver disease may cause toxic buildup. Hence Liver function tests (LFTs) should be monitored periodically. If you have cirrhosis or severe liver damage, your doctor may adjust the dose or consider an alternative.
Allergy
Contraindicated
Do not take MESACOL CR Granules 1gm if you are allergic to Mesalamine, Salicylates (e.g., Aspirin) or any other ingredients of this medicine.
Lungs
Use with Caution
MESACOL CR Granules 1gm should be used with caution in patients with lung problems such as bronchial asthma.
Use In Pediatrics
Use with Caution
MESACOL CR Granules 1gm is advised to be used with caution in children and adolescents (aged 6-18 years). Â
Use In Geriatrics
Use with Caution
MESACOL CR Granules 1gm should be used with caution in elderly patients (aged above 65 years).
Other Warnings for MESACOL CR GRANULES
Before taking MESACOL CR Granules 1gm inform your doctor if you:
- have an active peptic ulcer (stomach/duodenal ulcer)
Who should not take [GBNKEYWORD
MESACOL CR Granules 1gm is not recommended for use if you:
- suffer from bleeding disorders
Diet and Lifestyle Advice
Nutritional advice: Suggestions for diets that support management, including foods rich in vitamins and omega-3 fatty acids
- Vitamin D:Â salmon, fortified dairy, egg yolks
- Vitamin B12:Â Lean meats, eggs, fortified cereals
- Iron:Â Spinach (cooked), tofu
- Zinc:Â Nuts, seeds
- Anti-Inflammatory Omega-3-Rich Foods:Â Chia seeds, flaxseeds, walnuts
- Easily Digestible Carbohydrates:Â White rice, mashed potatoes, oatmeal, bananas, applesauce, peeled pears, pumpkin, zucchini, carrots
- Gut-Healing Proteins:Â Chicken, turkey
- Probiotic & Prebiotic Foods (only if well-tolerated): Yogurt (low-lactose), kefir, fermented foods, oats, bananas, garlic (if tolerated)
Lifestyle modifications: Tips on hydration, exercise, and stress management to enhance therapeutic outcomes
Hydration tips:
- Drink 8-10 glasses of water daily
- Choose electrolyte-rich drinks – Coconut water, diluted fruit juices, or oral rehydration solutions
- Avoid dehydrating beverages – Caffeine, soda and sugary drinks
- Monitor urine color – Light yellow means you are well-hydrated, dark yellow means you need more fluids.
Exercise for gut & overall health:
- Walking (30 min/day) – Improves blood circulation & digestion
- Stretching – Supports gut health & reduces stress
- Swimming & Cycling – Gentle on joints & reduces fatigue
- Strength training (Light weights) – Helps maintain muscle mass during flare-ups
Stress management: Reduce triggers for IBD Symptoms
- Mindfulness & Meditation:Â 10-15 minutes of deep breathing daily
- Journaling & Positive Affirmations:Â Helps manage anxiety about symptoms
- Acupuncture & Massage Therapy:Â May provide relief from IBD-related discomfort
- Engage in Hobbies:Â Painting, reading, or listening to music reduces stress
Improve sleep quality (essential for healing):
- Aim for 7-9 hours of sleep
- Create a bedtime routine
- Try herbal teas (chamomile, peppermint)
Drug – Drug interaction
Can I take MESACOL CR Granules 1gm with other medications?
1. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
- Examples:Â Ibuprofen, Naproxen, Aspirin, Diclofenac
- Why? May increase the risk of kidney damage when combined with mesalazine
- Alternative: Paracetamol (Acetaminophen) for pain relief
2. Blood Thinners (Anticoagulants)
- Examples:Â Warfarin, Heparin, Rivaroxaban, Apixaban
- Why? Mesalazine may enhance blood thinning effects, increasing the risk of bleeding or bruising
- Precaution: If you are on blood thinners, discuss dose adjustments with your doctor
3. Immunosuppressants
- Examples:Â Azathioprine, 6-Mercaptopurine, Methotrexate, Cyclosporine
- Why? Increased risk of bone marrow suppression and low blood cell counts
- Precaution:Â Routine blood tests may be required to monitor immune function
4. Proton Pump Inhibitors (PPIs)
- Examples:Â Omeprazole, Pantoprazole, Esomeprazole
- Why? May alter pH levels in the stomach, affecting mesalazine release and absorption
- Alternative:Â consider H2 blockers like Ranitidine or Famotidine (only if necessary)
5. Antibiotics
- Examples:Â Metronidazole, Ciprofloxacin, Amoxicillin
- Why? Some antibiotics may alter gut bacteria and worsen IBD symptoms
- Precaution:Â Probiotics may help restore gut balance if prescribed an antibiotic
6. Diuretics (Water Pills)
- Examples:Â Furosemide, Hydrochlorothiazide, Spironolactone
- Why? May cause excessive fluid loss, dehydration, and electrolyte imbalances
- Precaution:Â Stay hydrated and monitor kidney function if taking both medications
Synopsis
| Drug | :Â Â | Mesalamine |
| Pharmacological Category | :Â Â | Salicylates |
| Therapeutic Indication | :Â Â | Ulcerative colitis |
| Dosage Forms | :  | Tablets, Suppositories, Sachet, Granules, Powder, Pellet, Enema |
More Information
Alcohol Consumption:
1. Increased Gastrointestinal Irritation:
- Alcohol can irritate the stomach lining, increasing the risk of gastric pain, nausea, and diarrhea
- It may worsen ulcerative colitis symptoms and trigger flare-ups
2. Higher Risk of Liver Toxicity:
- Both Mesalazine and alcohol are metabolized by the liver
- Excessive alcohol use can strain the liver, potentially leading to hepatotoxicity (liver damage)
3. Dehydration & Worsened Symptoms:
- Alcohol acts as a diuretic, leading to fluid loss and worsening dehydration
- This may aggravate symptoms like diarrhea, abdominal cramping, and fatigue
4. Reduced Medication Effectiveness
- Chronic alcohol use may interfere with Mesalazine’s anti-inflammatory properties, making it less effective in controlling IBD
| Weight | 1 g |
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