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RIMACTANE 450mg Capsule 4's

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RIMACTANE 450mg Tablet 4’s

Name: RIMACTANE 450mg Tablet 4's
SKU: bp/med/302
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Original price was: ₹28.23.Current price is: ₹25.00.

4 Tablet(s) in a Strip * Mkt: Novartis India Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout

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SKU: bp/med/302 Category: Medicine

INTRODUCTION ABOUT RIMACTANE 450MG TABLET

RIMACTANE
450MG TABLET contains Rifampicin which belongs to the group of
medicines called Antibacterial. It is used to manage bacterial
infections such as tuberculosis (affects the lungs), legionnaires
disease (lung inflammation), brucellosis (infection spreading from
animal to person), leprosy (causes skin lesions and nerve damage) and
serious staphylococcal infections.

It also manages the infections
caused by Haemophilus influenzae and Neisseria meningitides (who are
the carriers but do not show the symptoms), thereby managing and
managing the onset of flu and meningitis. The doctor may ask you to take
blood tests and liver function tests before starting management with
RIMACTANE 450MG TABLET. RIMACTANE 450MG TABLET is not recommended for
use if you have yellowing of the skin and eyes (jaundice).

Before
taking RIMACTANE 450MG TABLET, it is recommended to inform your doctor
if you have liver, kidney problems, diabetes, are underweight or
malnourished, have a rare blood problem (porphyria), bleeding or a
tendency to bruise easily. Also, inform your doctor if symptoms of
tuberculosis return or get worse, are wearing contact lenses, are
vitamin K deficient or have hypoprothrombinemia (deficient clotting
factor).

RIMACTANE 450MG TABLET is not recommended for use in
pregnant and breastfeeding women. RIMACTANE 450MG TABLET should be used
with caution in children under 2 years of age and in elderly patients
above 65 years of age. The most common side effects seen are nausea,
vomiting, chills, fever. Consult your doctor if symptoms do not improve.

USES OF RIMACTANE 450MG TABLET

RIMACTANE 450MG TABLET is used to manage:

tuberculosis
leprosy
brucellosis
legionnaires
serious staphylococcal infections
infections caused by Haemophilus influenzae (causes flu) and Neisseria meningitides (causes meningitis)

HOW RIMACTANE 450MG TABLET WORKS

RIMACTANE
450MG TABLET works by managing protein synthesis and interferes with
the enzymes present in the bacteria causing its death. This results in a
reduction in the count of infection-causing bacteria, thereby managing
bacterial infections.

DIRECTIONS FOR USE

Take
RIMACTANE 450MG TABLET as advised by your physician. Swallow the
medicine with a glass of water. Do not crush or chew the medicine. It is
recommended to take RIMACTANE 450MG TABLET on an empty stomach. Your
doctor will decide the correct dose and duration for you depending on
your age, body weight and disease condition.

SIDE EFFECTS OF RIMACTANE 450MG TABLET

COMMON

headache, dizziness
nausea and vomiting
pyrexia (fever)
chills
thrombocytopenia with or without purpura (low platelet level)

RARE

Stop taking RIMACTANE 450MG TABLET and consult your doctor immediately if you experience any of the following:

allergic reactions such as swollen face, lips, tongue, throat causing difficulty in breathing and/or swallowing
skin
reactions characterized by fever, red colored circular patches on skin
with central blisters along with skin peeling and ulcers on mouth, nose,
throat and/or genitals, which may indicate Steven Johnson Syndrome
and/or Toxic Epidermal Necrolysis
severe watery, frequent loose stools and/or with presence of blood in it, along with weakness and/or fever
flu-
like symptoms along with the appearance of a rash which are widespread
in nature, increased temperature and enlarged lymph nodes which are
characteristic of DRESS (Drug Reaction with Eosinophilia and Systemic
symptoms)
development of purple spots and/or bruises on skin
severe headache
bleeding from various parts such as nose, ears, gums, throat
tender and/or swollen stomach
black tar-like stools
loss of weight, decreased blood sugar levels (hypoglycemia), dehydration, disorientation (adrenal insufficiency)
pain in abdomen along with increased blood pressure and rapid abnormal heartbeat, which may indicate Porphyria
red
and scaly rash which is widely spread on body with bumps under the skin
along with fever (acute generalized exanthematous pustulosis (AGEP))
altered amount of urine along with the presence of blood in it, feeling weak and drowsy (kidney problem)
dark urine along pale stools and yellowing of skin and eyes (liver problem)
return
of the original symptoms and/or increase in the severity of
pre-existing symptoms (Paradoxical Drug Reaction). ( associated with
fever, swollen lymph nodes (lymphadenitis), breathlessness, cough,
headaches, loss of appetite and weight loss)
swollen blood vessels in the skin
fever, chills, headache, dizziness and bone pain
mental problems causing a change in personality, hallucinations and odd behavior (psychotic disorder)

HOW TO MANAGE SIDE EFFECTS

Nausea and Vomiting:
Stick to simple meals. Avoid eating heavily rich or spicy food. Stay
hydrated. Consult your doctor if it persists for long or worsens with
time.

Headache:

Take some rest, in a
quiet place and avoid using mobile phones and other electronic devices
for a while. Drinking water as inadequate hydration may worsen your
headache. If symptoms persist, contact your doctor.

WARNING & PRECAUTIONS

PREGNANCY

RIMACTANE
450MG TABLETis not recommended for use in women who are pregnant and/or
planning pregnancy as it can affect the growth of your unborn baby and
may cause complications to the mother and baby after birth.

Also,
RIMACTANE 450MG TABLET may result in the ineffectiveness of oral
contraception, hence using physical methods of contraception like
condoms and coils are recommended. Always consult your doctor before
taking RIMACTANE 450MG TABLET.

BREASTFEEDING

RIMACTANE
450MG TABLET is not recommended to be taken by nursing women since it
may pass to the baby through mother’s milk. Consult your doctor before
taking RIMACTANE 450MG TABLET.

DRIVING AND USING MACHINES

It
is not recommended to drive and use heavy machinery after taking
RIMACTANE 450MG TABLET as it might make you feel dizzy or faint. It is
recommended to take RIMACTANE 450MG TABLET only after consultation with
the doctor.

KIDNEY

RIMACTANE
450MG TABLET must be taken with caution if you are diagnosed with any
kidney disease. Consult your doctor before taking RIMACTANE 450MG
TABLET.

LIVER

RIMACTANE
450MG TABLET must be taken caution if you are diagnosed with any
disease of the liver. Consult your doctor before taking RIMACTANE 450MG
TABLET.

ALLERGY

It
is not recommended to take RIMACTANE 450MG TABLET if you are allergic
to Rifampicin and/or any other drug present in RIMACTANE 450MG TABLET.

OTHERS

RIMACTANE 450MG TABLET is not recommended for use if you:

have yellowish tinge to eyes and skin which may be indicative of jaundice

Before taking RIMACTANE 450MG TABLET, inform your doctor if you:

are diagnosed with diabetes (elevated level of sugar in blood)
are underweight and/or malnourished
are diagnosed with a blood disorder called Porphyria characterized by the appearance of purple colored rash on skin
are prone to bleeding and/or bruising
wear contact lenses
have deficiency of Vitamin K
if symptoms of tuberculosis return or get worse
have hypoprothrombinemia (deficient clotting factor)

Use in Pediatrics:
RIMACTANE 450MG TABLET must be taken in caution in children below 2
years of age. Consult your doctor before taking it as they can decide
the correct and required dosage, frequency and strength of RIMACTANE
450MG TABLET based on age, disease condition and body weight of the
child.

Use in Geriatrics:
RIMACTANE 450MG
TABLET must be taken in caution in elderly patients (above the age of 65
years). Consult your doctor before taking RIMACTANE 450MG TABLET.

INTERACTIONS

A. Drug-Drug Interactions:

Before taking RIMACTANE 450MG TABLET, inform your doctor if you are taking any of the following medicine:

medicines used to manage HIV infection (Ex. saquinavir, ritonavir)
medicines used to manage indigestion such as antacids (Ex. aluminium hydroxide, magnesium carbonate)
other medicines used to manage tuberculosis (Ex. P-Aminosalicylic Acid)
medicines used to thin the blood (Ex. clopidrogel, warfarrin)
medicines used to lower cholesterol (Ex. atorvastatin, rosuvastatin)
medicines
for heart problems or to control your heartbeat (Ex. atenolol,
bisprolol), lower the blood pressure (Ex. diuretics like eplerenone)
medicines
used to manage thought disorders (Ex. antipsychotics like haloperidol),
reduce anxiety (Ex. hypnotics-lorazepam), to induce sleep (Ex.
barbiturates-phenobarbital), manage depression (Ex. amitriptyline)
medicines used to manage epilepsy (Ex. phenytoin), disease of motor neurons (Ex. riluzole)
medicines
used to manage various viral infections (Ex. indinavir, telaprevir,
amprenavir, nelfinavir, atazanavir, lopinavir, neviparine, daclatasvir,
simeprevir, sofosbuvir and telaprevir)
medicines used to manage
fungal diseases (Ex. ketoconazole, clotrimazole), bacterial infections
(Ex. amoxicillin, cephalosporin), tapeworm infections (Ex. praziquantel)
medicines used to lower the immune system response (Ex. ciclosporin, tacrolimus, sirolimus)
medicines used to manage pneumonia (Ex. atovaquone)
medicines used for contraception (Ex. estrogen, progestogens)
medicines
used to manage cancer (Ex. imatinib, irinotecan, ethinyloestradiol,
levonorgestrel or dydrogesterone), for breast cancer or endometriosis
(Ex. tamoxifen, gestrinone, toremifene)
medicines used to manage thyroid gland problems (Ex. levothyroxine)
medicines
used to manage gout and other pains (Ex. aspirin, etoricoxib, codeine,
morphine, fentanyl, pethidine, etoricoxib, aspirin and indomethacin)
medicines used to manage inflammation in the body such as corticosteroids (Ex. hydrocortisone, betamethasone and prednisolone)
medicines used during withdrawal from heroin (Ex. methadone)
medicines used to manage diabetes (Ex. metformin)
medicines used before surgery to relax the mind and body (Ex. halothane)
medicines used for nausea (Ex. ondansetron, aprepitant)
medicines used for malaria (Ex. quinine)
medicines used to manage difficulty breathing and wheezing sound (Ex. theophylline)

Overdosage:

If
you or anyone else accidentally took too much of RIMACTANE 450MG
TABLET, visit the nearby hospital or consult your doctor immediately.
Signs and symptoms of overdosage are feeling sick (nausea) along with
vomiting and pain in abdomen, increased itch (pruritus), headache and
increased lethargy, feeling of drowsiness, swelling of the face, eyes or
eyelids, fast or uneven heartbeat, dizziness, fits and heart attack.

SYNOPSIS

Drug	:	Rifampicin
Pharmacological Category	:	Antibacterial
Therapeutic Indication	:	Bacterial infections
Dosage Forms	:	Syrup, Capsule, Tablet, Suspension

MORE INFORMATION

Keep RIMACTANE 450MG TABLET out of reach of children
Keep RIMACTANE 450MG TABLET away from heat
Keep it below 25°C

FAQs ABOUT RIMACTANE 450MG TABLET

What is RIMACTANE 450MG TABLET used for?
RIMACTANE 450MG TABLET is used to manage bacterial infections such as
tuberculosis (affects the lungs), legionnaires disease (lung
inflammation), brucellosis (infection spreading from animal to people),
leprosy (causes skin lesions and nerve damage) and serious
staphylococcal infections. It also manages the infections caused by
Haemophilus influenzae and Neisseria meningitides (who are the carriers
but do not show the symptoms), thereby managing and managing the onset
of flu and meningitis.

How does RIMACTANE 450MG TABLET work?
RIMACTANE 450MG TABLET works by managing protein synthesis and
interfering with the enzymes present in the bacteria causing its death.
This results in a reduction in the count of infection-causing bacteria,
thereby managing bacterial infections.

When should I not take RIMACTANE 450MG TABLET?
RIMACTANE 450MG TABLET is not recommended to be taken if you are
allergic to Rifampicin and/or any other constituent of RIMACTANE 450MG
TABLET, have yellowish tinge to eyes and skin which may be indicative of
jaundice and/or are diagnosed with HIV infection.

Can I drive while taking RIMACTANE 450MG TABLET?
It is not recommended to drive and use heavy machinery after taking
RIMACTANE 450MG TABLET as it might make you feel dizzy or faint. It is
recommended to take RIMACTANE 450MG TABLET only after consultation with
the doctor.

Can RIMACTANE 450MG TABLET be taken with Vitamin D?
Taking RIMACTANE 450MG TABLET with Vitamin D will decrease the effect
of Vitamin D. Inform your doctor if you are taking this medicine as the
dose will be adjusted accordingly.

REFERENCES

1. KD. Tripathi. Antitubercular Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page- 675.

2. KD. Tripathi. Antileprotic Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page- 685.

3.
Niemi, M., Backman, J.T., Fromm, M.F., Neuvonen, P.J. and Kivistö, K.T.
Pharmacokinetic interactions with rifampicin. Clinical
pharmacokinetics. Springer link. 2003 [Accessed on 12th September 2022] https://link.springer.com/article/10.2165/00003088-200342090-00003

4.
McClure, W.R. and Cech, C.L. On the mechanism of rifampicin inhibition
of RNA synthesis. Journal of Biological Chemistry. December 1978
[Accessed on 12th September 2022] https://www.sciencedirect.com/science/article/pii/S0021925817342692

5. Gerard Laboratories. Electronic Medicines Compendium (EMC) [Revised in June 2022] [Accessed on 12th September 2022] https://www.medicines.org.uk/emc/files/pil.8788.pdf

6. Gerard Laboratories. Electronic Medicines Compendium (EMC) [Revised in June 2022] [Accessed on 12th September 2022] https://www.medicines.org.uk/emc/files/pil.8789.pdf , https://www.medicines.org.uk/emc/product/8789/smpc

7. Sanofi-aventis U.S. LLC. U.S. Food & Drug Administration. [Revised in November 2010] [Accessed on 12th September 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/050420s073,050627s012lbl.pdf

USEFUL DIAGNOSTIC TESTS

Liver Function Test (LFT)
Complete Blood Count (CBC)
Blood Glucose Level

Weight	17.5 g

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INTRODUCTION ABOUT RIMACTANE 450MG TABLET

USES OF RIMACTANE 450MG TABLET

HOW RIMACTANE 450MG TABLET WORKS

DIRECTIONS FOR USE