- 5%
Saaz DS Tablet 10’S
Original price was: ₹192.90.₹182.90Current price is: ₹182.90.
*10 Tablet(s) in a Strip* Delivery charges if applicable will be applied at checkout
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Introduction About SAAZ DS TABLET
Saaz DS Tablet 10’S is a prescription medication used for the management of rheumatoid arthritis, ulcerative colitis, and Crohn’s disease. It helps reduce inflammation and relieve symptoms effectively.
Your doctor might want you to take certain blood, kidney and liver function tests during the management. Drink enough fluids during this management to avoid problems with kidney.
Before taking SAAZ DS TABLET inform your doctor if you have porphyria (a rare blood pigment disorder), jaundice, kidney, liver, blood problems, glucose-6-phosphate dehydrogenase deficiency, history of recurring chronic infection, asthma, arthritis.
Inform your doctor if you are pregnant or breastfeeding. SAAZ DS TABLET is not recommended for use in children below 2 years of age.
The most common side effects of taking SAAZ DS TABLET are indigestion, heartburn, nausea, dizziness and headache. Consult your doctor if side effects gets worse.
Key Composition
- Sulfasalazine
Uses Of SAAZ DS TABLET
It is used to manage:
- Ulcerative colitis
- Crohn’s disease
- Rheumatoid arthritis
Benefits of SAAZ DS TABLET
1. Reduces Inflammation
- Helps control joint inflammation in rheumatoid arthritis (RA), reducing pain and swelling.
- Acts on the intestines to reduce inflammation in ulcerative colitis and Crohn’s disease?
2. Saaz DS for Rheumatoid Arthritis
- Classified as a Disease-Modifying Anti-Rheumatic Drug (DMARD), meaning it prevents joint damage and long-term disability in arthritis patients?
3. Supports Gut Health in IBD (Inflammatory Bowel Disease)
- The 5-aminosalicylic acid (5-ASA) component of Saaz DS helps in healing the gut lining and reducing symptoms of diarrhea, abdominal pain, and bleeding?
4. Immunomodulatory Effect
- Suppresses overactive immune responses, preventing the immune system from attacking healthy joint or gut tissues in autoimmune disorders?.
5. Effective Long-Term Management
- When taken consistently, Saaz DS can help patients achieve remission in ulcerative colitis and prevent flare-ups?
6. Alternative to Steroids
Often prescribed as an alternative to corticosteroids, which have more severe long-term side effects
How SAAZ DS TABLET Works
Saaz DS (Sulfasalazine) is a disease-modifying anti-rheumatic drug (DMARD) that works primarily by targeting inflammation in the body, especially in the joints and digestive tract
Mechanism of Action:
- Anti-inflammatory Action: Saaz DS contains sulfasalazine, which breaks down in the body to produce 5-aminosalicylic acid (5-ASA) and sulfapyridine. The 5-ASA component is primarily responsible for the anti-inflammatory effects. It acts by:
- Inhibiting inflammatory cytokines: 5-ASA reduces the production of inflammatory molecules like prostaglandins and leukotrienes, which are responsible for causing inflammation.
- Suppressing immune response: It can dampen the activation of certain immune cells, thereby helping to control autoimmune reactions, especially in conditions like rheumatoid arthritis and ulcerative colitis.
- Modulation of Immune Response: Sulfasalazine and its metabolites, particularly sulfapyridine, have immune-modulating effects that help reduce the overactivity of the immune system that is typical in conditions like rheumatoid arthritis. It decreases T-cell activation, macrophage function, and the release of interleukins, which are involved in the inflammatory process.
- Impact on the Gastrointestinal Tract:
- In conditions like ulcerative colitis and Crohn’s disease, Saaz DS works directly on the intestines, reducing inflammation and promoting healing of the digestive lining. This is particularly useful in conditions where the immune system mistakenly attacks the gastrointestinal system.
- The 5-ASA released in the colon targets the inflammation specific to the intestines, leading to improved symptom control in IBD (Inflammatory Bowel Disease).
- Reduction in Joint Inflammation: In rheumatoid arthritis, Saaz DS works by modulating the immune system’s response, reducing joint inflammation, and preventing further damage to the joints. It can also help reduce the need for steroids or other stronger medications.
How to use SAAZ DS TABLET
1.Recommended Dosage for Adults
- Rheumatoid Arthritis: Typically, the dose is 500 mg to 1,000 mg, taken once or twice a day, depending on the severity of the condition. The dosage may be gradually increased by your doctor.
- Ulcerative Colitis: The usual dosage is 1,000 mg to 2,000 mg per day, divided into two doses. Again, this can vary based on your physician’s recommendation based on your condition’s severity.
- Always follow your doctor’s instructions on the exact dosage.
2. Can Saaz DS be Taken on an Empty Stomach?
- Swallow the tablet whole with a glass of water.
- It can be taken with food or on an empty stomach, depending on how it affects your stomach.
- It is often advised to take it after a meal if gastrointestinal discomfort occurs.
3. How long should one take Saaz DS Tablet?
- Chronic Conditions: Treatment is usually long-term, and it may take several weeks to notice the full benefits, especially for conditions like rheumatoid arthritis or ulcerative colitis.
- Continuous Monitoring: Regular blood tests (for liver and kidney function) and monitoring for side effects like blood disorders are necessary during treatment.
4. How Soon Does Saaz DS Start Working?
For Rheumatoid Arthritis:
- Initial Effects: Sulfasalazine may start providing some symptom relief within 2 to 4 weeks of starting the medication. However, it can take up to 12 weeks for the full therapeutic effects to be noticed.
- Long-Term Use: It often takes longer for Saaz DS to significantly reduce joint inflammation, pain, and stiffness, especially in chronic conditions like rheumatoid arthritis.
 For Ulcerative Colitis:
- Onset of Action: In treating ulcerative colitis, some patients may notice improvements within 2 to 4 weeks, but for the drug to provide significant control over flare-ups, it can take up to 6 to 8 weeks.
- Maintenance: Once the medication begins to work, it can help maintain remission, reducing the frequency and severity of flare-ups over the long term.
For Crohn’s Disease:
- Similar to ulcerative colitis, the onset of effects may take 4 to 6 weeks, though some patients may require several months to experience maximum benefit.
5. Can I stop taking Saaz DS suddenly?
- No, Saaz DS (Sulfasalazine) should not be stopped suddenly without consulting a healthcare provider. Stopping the medication abruptly, especially for conditions like rheumatoid arthritis, ulcerative colitis, or Crohn’s disease, can lead to a flare-up of symptoms or worsening of the condition.
- Always talk to your doctor before stopping Saaz DS. They will guide you on the appropriate method to discontinue or adjust your medication, especially if you are experiencing side effects or if your condition has improved.
- In some situations, if you’re no longer experiencing symptoms, your doctor may slowly taper the dosage to minimize the risk of flare-ups.
6. Is Saaz DS Safe for Long-Term Use?
Saaz DS (Sulfasalazine) is generally considered safe for long-term use when prescribed by a healthcare provider and when used to manage chronic conditions like rheumatoid arthritis, ulcerative colitis, or Crohn’s disease. However, long-term use should always be monitored closely due to potential side effects and risks.
Safety Considerations for Long-Term Use:
Potential Side Effects:
- Gastrointestinal Issues: Some people experience nausea, vomiting, or abdominal pain, especially when starting the medication. These effects typically lessen over time.
- Hematological Effects: Sulfasalazine can occasionally cause blood disorders such as low white blood cell count (leukopenia), anemia, or thrombocytopenia. Regular blood tests are recommended to monitor for these issues.
- Liver Toxicity: Prolonged use may sometimes affect liver function. It is important to have liver function tests performed regularly, particularly in those with pre-existing liver conditions.
- Pulmonary Issues: Rarely, Sulfasalazine has been associated with pulmonary toxicity, leading to breathing difficulties or lung damage. This can be more problematic in individuals with pre-existing lung disease.
Monitoring for Long-Term Safety:
- Regular Check-ups: Long-term users should have periodic blood tests, including complete blood counts (CBC) and liver function tests, to detect early signs of any side effects.
- Kidney Function: Monitoring kidney function is also crucial, as Saaz DS is metabolized by the liver and excreted through the kidneys.
- Eye Health: While rare, eye problems such as retinal toxicity can occur, so monitoring eye health during long-term use may be advised in some cases.
What if I forgot to take SAAZ DS TABLET
- If you miss a dose, take it as soon as you remember.
- If the next dose is near, skip the missed dose—do not take two doses at once to make up for the missed one.
Side Effects Of SAAZ DS TABLET
Like all medicines, Saaz DS Tablet may cause certain side effects in some individuals, although not everybody gets them.
Some of the Common Side Effects of Saaz DS Tablet are:
- indigestion
- heartburn
- nausea
- dizziness
- headache
- changes in taste
- ringing in the ears
- cough
- itching of the skin
- purple discolorations on the skin
- joint pain
- protein in urine
- fever
Serious Side Effects (When to Seek Medical Help):
- allergic reaction such as sudden wheeziness, difficulty in breathing, swelling of eyelids, face or lips, rash or itching (affecting the whole body)
- jaundice
- severe skin rash that causes blistering (affects the mouth and tongue), life-threatening skin rashes (exfoliate dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis)
- fever, pains in your joints, hives, swollen glands, rash and itching (signs of serum sickness)
- any unexplained bleeding
- bruising, fever, rash, pallor (paleness), severe sore throat or tiredness (signs of abnormality in blood)
- rash or fever or swollen gland may be a sign of DRESS (drug rash with eosinophilia and systemic symptoms)
How To Manage Side Effects
Cough And Cold
- Honey: Honey has soothing properties that can help reduce throat irritation and suppress cough. Take a spoonful of raw honey or mix it into warm tea.
- Hydration: Keep your throat moist by drinking warm fluids like tea with honey or water.
- Steam Inhalation: Breathing in steam from a hot shower or a bowl of hot water can loosen mucus and relieve a dry or wet cough.
- Cough Syrup: Over-the-counter cough syrups or lozenges can help calm coughing, especially if it’s due to irritation or minor throat inflammation.
Headache
- Hydration: Dehydration is a common cause of headaches. Drink plenty of water to stay hydrated.
- Rest: Ensure adequate rest, as lack of sleep can contribute to headaches.
- Cold or Warm Compress: Applying a cold compress to the forehead or a warm compress to the back of the neck can alleviate tension headaches.
- Over-the-Counter Pain Relief: Ibuprofen, acetaminophen, or aspirin can help relieve mild to moderate headaches. However, consult a doctor if headaches are frequent or severe.
Indigestion
- Avoid Trigger Foods: Spicy, fatty, or acidic foods can trigger indigestion. Try to avoid them until symptoms subside.
- Eat Slowly: Eating too quickly can lead to indigestion. Take smaller bites and chew your food thoroughly.
- Antacids: Over-the-counter medications like antacids can help neutralize stomach acid and provide relief.
- Herbal Teas: Peppermint tea or chamomile tea may help relax the stomach muscles and reduce discomfort.
Nausea And Vomiting
- Ginger: Known for its anti-nausea properties, ginger tea or ginger supplements can soothe an upset stomach.
- Small, Frequent Meals: Eating smaller meals more frequently throughout the day can prevent nausea. Avoid large or greasy meals.
- Stay Upright: After eating, avoid lying down, as this can worsen nausea.
- Fresh Air: Sometimes, stepping outside for fresh air can help relieve the sensation of nausea.
Warning & Precautions
Pregnancy
Consult your doctor
Inform your doctor if you are pregnant or planning to have a baby before taking SAAZ DS TABLET. Your doctor will decide whether to take it or not.
Breastfeeding
Consult your doctor
Avoid breastfeeding while taking SAAZ DS TABLET as there have been reports of diarrhea or blood in the stools in nursing babies. Consult your doctor before taking it.
Driving and Using Machines
Safe
SAAZ DS TABLET is unlikely to affect your ability to drive or use machines.
Kidney
Use with Caution
SAAZ DS TABLET should be used with caution in patients with kidney disease. Consult your doctor before taking. It’s important to regularly monitor serum creatinine levels, glomerular filtration rate (GFR), and electrolyte levels to ensure the kidneys are functioning properly and to adjust medications accordingly.
Liver
Use with Caution
SAAZ DS TABLET should be used with caution in patients with liver disease. Consult your doctor before taking. Liver function tests (LFTs) should be regularly monitored to assess whether the liver is handling medications effectively.
Allergy
Contraindicated
Do not take SAAZ DS TABLET if you are allergic to Sulfasalazine, salicylates (Ex. aspirin) or sulfonamides (type of antibiotic) or any other ingredients of this medicine.
Lungs
Use with Caution
SAAZ DS TABLET should be used with caution in patients with asthma. Consult your doctor before taking.
Use In Pediatrics
Consult your doctor
Children and adolescents aged below 18 years must consult your doctor before taking SAAZ DS TABLET. It is not recommended for use in children below 2 years of age. Hence, consult your doctor for a suitable alternative.
Use In Geriatrics
Use with Caution
SAAZ DS TABLET should be used with caution in elderly patients. Consult your doctor before taking.
Other Warnings for SAAZ DS TABLET
Before taking SAAZ DS TABLET, inform your doctor if you:
- have blood disorders
- have glucose-6-phosphate dehydrogenase deficiency (an inherited condition)
- have a history of recurring chronic infections
- your child has arthritis
Who should not take [GBNKEYWORD
- have porphyria (a rare blood pigment disorder)
- have jaundice
Diet and Lifestyle Advice
1. Diet Recommendations:
A healthy diet is essential for supporting the immune system and managing symptoms associated with conditions treated by Saaz DS.
For Rheumatoid Arthritis:
- Anti-inflammatory foods: Incorporate foods rich in omega-3 fatty acids (like salmon, chia seeds, and walnuts), fiber, and antioxidants (found in fruits, vegetables, and whole grains) to reduce inflammation.
- Avoiding triggers: Some people with autoimmune diseases may benefit from avoiding foods that could exacerbate inflammation, such as processed sugars, refined carbohydrates, and saturated fats.
For Ulcerative Colitis:
- Low-fiber and bland foods during flare-ups: Foods that are easy to digest, like white rice, applesauce, and bananas, may help during flare-ups. This reduces irritation to the digestive tract.
- Probiotics: Foods like yogurt and fermented foods (kimchi, sauerkraut) can support gut health, but it’s important to consult your doctor before introducing them, especially during active flare-ups.
For Crohn’s Disease:
- Balanced meals: A diet rich in lean proteins (chicken, tofu), low-fat dairy, and well-cooked vegetables can help avoid digestive irritation.
- Nutrient-dense foods: Crohn’s disease can lead to malabsorption, so focusing on nutrient-dense foods such as leafy greens, legumes, and smooth nut butters can help fill nutrient gaps.
2. Exercise Recommendations:
Exercise can significantly improve joint health, mobility, and overall physical well-being. The key is to balance low-impact activities with those that enhance flexibility and strength.
For Rheumatoid Arthritis:
- Low-impact activities: Exercises like swimming, cycling, and walking can reduce strain on the joints while improving flexibility and cardiovascular health.
- Strength training: Incorporating light resistance exercises (e.g., resistance bands, light weights) helps build muscle strength around the joints, supporting their function and reducing the risk of further joint damage.
For Ulcerative Colitis and Crohn’s Disease:
- Moderate exercise: Low to moderate exercises like yoga, walking, and cycling can help improve digestive function, reduce stress, and maintain overall health.
- Manage flare-ups: During flare-ups of inflammatory bowel diseases (IBD), rest is crucial, but gentle stretching and walking may help with overall recovery.
3. Lifestyle Changes:
Certain lifestyle changes can enhance the effectiveness of Saaz DS and improve quality of life.
Stress Management:
- Mind-body techniques like yoga, deep breathing, and meditation can reduce stress, which is known to exacerbate both autoimmune diseases and gastrointestinal conditions. Chronic stress increases inflammation in the body, so managing it can help improve symptoms.
- Adequate sleep: Getting 7-9 hours of sleep each night is crucial for immune system regulation and overall health.
Regular Medical Check-ups:
- Stay up-to-date with routine check-ups, especially for people on long-term medications like Saaz DS. Regular blood tests to monitor for side effects like liver or kidney function, or blood count issues, are crucial.
- If you experience side effects or new symptoms, talk to your healthcare provider promptly.
Smoking and Alcohol:
- Avoid smoking as it increases the risk of flare-ups in autoimmune diseases and negatively affects lung health and circulation.
- Limit alcohol consumption, as it can irritate the gastrointestinal tract and interact negatively with medications like Saaz DS.
Drug – Drug interaction
Methotrexate:
Both Sulfasalazine and Methotrexate are immunosuppressive agents. When taken together, there is an increased risk of bone marrow suppression, which can lead to lower white blood cell counts, anemia, and thrombocytopenia.
Warfarin (Coumadin):
Sulfasalazine can enhance the effects of Warfarin, increasing the risk of bleeding. This is because Sulfasalazine can alter vitamin K metabolism, which is critical for clotting.
Antacids and Iron Supplements:
Antacids and iron supplements can reduce the absorption of Sulfasalazine in the gastrointestinal tract, making the medication less effective.
Aspirin and Nonsteroidal Anti-Inflammatory Drugs (NSAIDs):
Both Sulfasalazine and NSAIDs can potentially cause gastric irritation or ulcers, and taking them together can increase the risk of gastrointestinal bleeding.
Azathioprine:
Azathioprine and Sulfasalazine are both immunosuppressants, and taking them together may increase the risk of infections or bone marrow suppression.
| Weight | 17.5 g |
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