INTRODUCTION ABOUT DUOVIR E KIT
DUOVIR
E KIT is a combination of Efavirenz, Lamivudine, Zidovudine which
belongs to the group of medicines called Antiretroviral drugs. It is
used for the management of human immunodeficiency virus (HIV) infection
in adults.
HIV is the Human Immunodeficiency Virus which severely
damages the immune system and lead to Acquired Immune Deficiency
Syndrome (AIDS) which is characterized by fever, chills, rash, night
sweat, muscle aches, sore throat, fatigue.
DUOVIR E KIT should be
used in caution with patient having liver, kidney and heart disease.
Consult your doctor for advice before taking the medicine.
DUOVIR
E KIT should be used with caution in pregnant woman. It is not
recommended for use in breastfeeding women as it may pass through the
breastmilk. Consult your doctor for advice before taking the medicine.
DUOVIR
E KIT is not recommended for use in children. Consult your doctor for
advice. DUOVIR E KIT should be used with caution in patients above 65
years of age.
The most common side effects of taking DUOVIR E KIT
are dizziness, nausea, headache, diarrhea. Consult your doctor if the
side effects worsens or persists for a longer duration.
USES OF DUOVIR E KIT
- Used to manage human immunodeficiency virus (HIV) infection
HOW DUOVIR E KIT WORKS
DUOVIR
E KIT contains Efavirenz, Lamivudine, Zidovudine which collectively
works against the HIV infection by blocking the action of the reverse
transcriptase enzyme, which is essential for the virus to multiply and
therefore it reduces the amount of HIV in the body.
DIRECTIONS FOR USE
Take
DUOVIR E KIT as advised by your physician. Swallow this medicine do not
crush or chew the medicine. Your doctor will decide the correct dose
and duration for you depending upon your age, body weight and disease
condition.
SIDE EFFECTS OF DUOVIR E KIT
COMMON
- skin rash
- abnormal dreams
- tiredness or malaise
- fatigue
- dizziness
- nausea or vomiting
- trouble in sleeping, insomnia (lack of sleep)
- headache
- fever or chills
- difficulty concentrating
- diarrhea
- anorexia (loss of appetite) or decreased appetite
- abdominal pain, abdominal cramps
- dyspepsia (upper abdominal discomfort)
- weakness, numbness and pain from nerve damage
- depressive disorders
- nasal signs and symptoms like cough
- myalgia (muscle pain)
- arthralgia (joint pain)
RARE
Stop taking DUOVIR E KIT and contact your doctor immediately if you experience any of the following side effects:
- signs
of lactic acidosis such as feeling of weakness or tiredness, cold,
muscle pain, dizziness or light-headedness, breathing problems, fast or
irregular heartbeat - signs of serious liver problems like
yellowing of skin or the white part of eyes (jaundice), nausea (feel
sick), dark urine, light coloured stools, abdominal pain - worsening of hepatitis B virus (HBV) with signs of fever, joint pain, dark urine
- signs
of serious mental health problems like feeling sad or hopeless,
anxiety, restlessness, hallucinations, self-harming thoughts - signs of nervous system problems like dizziness, trouble in concentrating and sleeping, unusual dreams, lack of coordination
- skin
rash with or without itching, peeling skin, mouth sores, fever,
swelling of your face, red or inflamed eyes, like pink eye
(conjunctivitis), blisters or skin lesions - anemia
- seizures (fits)
- changes in immune system
- changes in body fat seen as increased amount of fat in the upper back and neck, breast and around the main part of your body
- risk of inflammation of the pancreas (pancreatitis)
HOW TO MANAGE SIDE EFFECTS
Diarrhoea:
To
avoid dehydration in your body, drink plenty of fluids such as water,
fruit juices or electrolytes. If the condition worsens, consult your
physician immediately.
Nausea or Vomiting:
Take
this medicine with or just after meals. Stick to simple meals. Avoid
eating oil rich or spicy foods. Consult your doctor if there is no
improvement in symptoms.
Headache:
Apply
hot or cold-water bag on your head. Try to take rest in a quiet and dark
room. Drink tea or coffee. Massage the scalp or head with mild
pressure. Consult your doctor for advice.
Skin rash:
Try
to avoid hot showers because it may cause skin irritation. Avoid
frequent contact and rubbing over the affected area. Use sunscreen and
protective clothing when outdoors. If this symptom does not get better,
speak to a doctor.
WARNING & PRECAUTIONS

PREGNANCY
DUOVIR
E KIT should be used with caution in pregnant woman or if you are
planning to become pregnant. Women should use effective contraception
during management with DUOVIR E KIT and for 12 weeks after
discontinuing. Consult your doctor before taking it.

BREASTFEEDING
DUOVIR
E KIT is not recommended for use in breastfeeding women as it may pass
through the breastmilk. Consult your doctor for advice before taking
DUOVIR E KIT.

DRIVING AND USING MACHINES
Do
not drive or operate any machines if you feel dizziness or trouble in
concentrating after taking DUOVIR E KIT. Consult your doctor before
taking DUOVIR E KIT.

ALCOHOL
Avoid consumption of alcohol as it may increase the risk of side effects. Consult your doctor for advice.

KIDNEY
DUOVIR E KIT should be taken with caution in patients having kidney problems. Consult your doctor before taking DUOVIR E KIT.

LIVER
DUOVIR
E KIT should be taken with caution in patients having liver problems,
including hepatitis B or C virus infection. Consult your doctor before
taking DUOVIR E KIT.

ALLERGY
Do not take DUOVIR E KIT if you are allergic to Efavirenz, Lamivudine, Zidovudine or any other ingredients of this medicine.

HEART DISEASE
DUOVIR E KIT should be taken with caution in patients having heart problems. Consult your doctor before taking DUOVIR E KIT.
OTHERS
Before taking DUOVIR E KIT, inform your doctor if you:
- have diabetes
- have or ever had a mental health problem
- have a history of seizures
Use in Pediatrics:
DUOVIR E KIT is not recommended for use in children. Consult your doctor before taking DUOVIR E KIT.
Use in Geriatrics:
DUOVIR
E KIT should be used with caution in elderly patients above 65 years of
age. Before taking DUOVIR E KIT, consult your doctor for advice.
INTERACTIONS
A. Drug – Drug interactions:
- medicines used to manage HIV infection (Ex. emtricitabine, tenofovir disoproxil fumarate)
Overdosage:
If you or anyone else accidentally takes too much of DUOVIR E KIT, consult your doctor immediately or visit nearby hospital.
SYNOPSIS
Drug | :Â Â | Efavirenz, Lamivudine, Zidovudine |
Pharmacological Category | :Â Â | Antiretroviral drugs |
Therapeutic Indication | :Â Â | Human immunodeficiency virus infection |
Dosage Forms | :Â Â | Tablet, Kit |
MORE INFORMATION
- Keep DUOVIR E KIT out of reach of children
- Store at room temperature
FAQs ABOUT DUOVIR E KIT
Q: How does DUOVIR E KIT works?
A:
DUOVIR E KIT contains Efavirenz, Lamivudine, Zidovudine which
collectively works against the HIV infection by blocking the action of
the reverse transcriptase enzyme, which is essential for the virus to
multiply and therefore it reduces the amount of HIV in the body.
Q: Can DUOVIR E KIT be given to children and elderly patients?
A:
DUOVIR E KIT is not recommended for use in children and it should be
used with caution in elderly patients above 65 years of age. Before
taking DUOVIR E KIT consult your doctor.
Q: Can DUOVIR E KIT be used during pregnancy?
A:
DUOVIR E KIT should be used with caution in pregnant woman or if you
are planning to become pregnant. Women should use effective
contraception during management with DUOVIR E KIT and for 12 weeks after
discontinuing. Consult your doctor before taking it.
Q: Does DUOVIR E KIT cause dizziness?
A:
Yes, dizziness is one of the common side effects of DUOVIR E KIT. When
you feel dizzy, lie or sit down immediately. If you’re experiencing a
severe episode of vertigo, lie in a dark and quite place with eyes
closed. Vehicle driving should be avoided if you experience frequent
dizziness without warning. Talk to your doctor if the symptom worsens.
Q: Does DUOVIR E KIT be given to patients with liver, kidney and heart disease?
A:
DUOVIR E KIT should be used with caution in patients having liver
problems including hepatitis B or C virus infection, kidney and heart
problems. Consult your doctor before taking DUOVIR E KIT.
REFERENCES
1. KD. Tripathi. Antiretroviral drugs. Essentials of medical pharmacology. Eighth edition. 2019. Page –861-863.
2.
Natella Y. Rakhmanina and John N. van den Anker. Efavirenz in the
Therapy of HIV Infection. National Library of Medicine, National center
for biotechnology information. PubMed Central. Revised in January 2011.
[Accessed 5th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810555/
3.
Katherine Taylor;Â Kristina Fritz;Â Mayur Parmar. Lamivudine. National
Library of Medicine, National center for biotechnology information.
StatPearls. May 2013. [Accessed 5th July 2022] https://www.ncbi.nlm.nih.gov/books/NBK559252/
4.
Zachary Edwards, Curtis J Ingold. Zidovudine. National Library of
Medicine, National center for biotechnology information. StatPearls.
June 2022. [Accessed 5th July 2022] https://www.statpearls.com/ArticleLibrary/viewarticle/31466#/
5. Cipla Ltd. Revised in July 2020. [Accessed 5th July 2022] https://ciplamed.com/content/duovir-e-kit
USEFUL DIAGNOSTIC TESTS
- Antibody test
- Complete blood count
Weight | 15 g |
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