- 1%
Isordil 10mg Tablet 10’S
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INTRODUCTION
ISORDIL 10MG contains Isosorbide dinitrate which belongs to the group of medicines called Nitrate Vasodilators. It is used to prevent angina pectoris due to coronary artery disease and helps to control certain types of heart failure.
Angina pectoris is defined as a sudden, sharp, severe pain originating from the apex of heart and radiating to the left shoulder. The pain is severe and crushing, and it is characterized by feeling of pressure and suffocation, behind breastbone.
ISORDIL 10MG is not recommended for use if you have anaemia, had a heart attack, bleeding in the brain, head injury, very low blood pressure, low blood volume (hypovolaemia). Before taking ISORDIL 10MG, inform your doctor if you have any liver, kidney, heart, or thyroid problems, glaucoma, or extremely low body temperature. Avoid consumption of alcohol during management with ISORDIL 10MG as it may increase the risk of low blood pressure.
If you are pregnant or think you might be pregnant or planning to have a baby ask your doctor for advice before taking this medicine. ISORDIL 10MG should be used with caution in breastfeeding women. Consult your doctor before taking it. Along with the management, your doctor might advice you to make certain lifestyle changes such as quitting alcohol and smoking, improve your sleep at night, eating a healthy diet and manage weight.
The most common side effects of taking ISORDIL 10MG are headache, low blood pressure, dizziness when standing up, rapid heartbeat, drowsiness, tiredness, and swelling of the hands, ankles, or feet. Contact your doctor if any of the symptoms get worse.
USES OF ISORDIL 10MG
- Prevents angina pectoris
- Helps to control certain types of heart failure
HOW ISORDIL 10MG WORKS
ISORDIL 10MG works by relaxing the blood vessels of the heart and this reduces the strain on the heart making it easier to pump blood, thereby it provides relief from anginal symptoms.
DIRECTIONS FOR USE
Take ISORDIL 10MG as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you based upon your age and disease condition. Do not stop taking ISORDIL 10MG unless your doctor advises you to stop.
SIDE EFFECTS OF ISORDIL 10MG
COMMON
- headache
- decrease in blood pressure, dizziness or fainting when standing up due to low blood pressure
- rapid heartbeat
- drowsiness, tiredness, weakness
- swelling of the hands, ankles or feet
UNCOMMON
- nausea or vomiting
- skin rashes or flushing
- collapsing with slow or irregular heartbeat and fainting
Stop taking ISORDIL 10MG and contact your doctor immediately if you experience any of the following side effects:
- signs or symptoms of cerebral ischaemia (stroke) (such as weakness in one arm or leg or one entire side of the body, slurred speech and loss of coordination)
- worsening of angina due to very low blood pressure
- allergic reaction symptoms such as rash, itching or difficulty breathing
HOW TO MANAGE SIDE EFFECTS
Headache:
Take rest and drink plenty of water. Try to be relaxed and stress free. Apply pain relieving balm on the forehead if necessary. Consult your doctor if the symptom does not improve.
Dizziness:
Try to rest and relax and get enough sleep. Try to avoid driving or operating any tools or machines while you are feeling dizzy. Limit your consumption of alcohol, as it can aggravate your dizziness. Consult and inform your doctor if the symptom does not improve.
Nausea or vomiting:
Try to take ISORDIL 10MG with or just after a meal or a snack. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if the symptom gets worse.
WARNING & PRECAUTIONS
PREGNANCY
ISORDIL 10MG is not recommended for use during pregnancy unless considered clearly necessary. Consult your doctor before taking ISORDIL 10MG.
BREASTFEEDING
ISORDIL 10MG should be used with caution in breastfeeding women. Consult your doctor before taking ISORDIL 10MG.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you experience headache, tiredness or dizziness after taking ISORDIL 10MG.
ALCOHOL
Avoid consumption of alcohol while taking this medicine, because it may raise the blood pressure lowering effect of this medicine.
KIDNEY
ISORDIL 10MG should be used with caution in patients with severe kidney problems. Consult your doctor before taking ISORDIL 10MG.
LIVER
ISORDIL 10MG should be used with caution in patients with severe liver problems. Consult your doctor before taking ISORDIL 10MG.
ALLERGY
Do not take ISORDIL 10MG if you are allergic to Isosorbide dinitrate or other nitrates (such as isosorbide mononitrate, nitroglycerin) or any of the other ingredients of this medicine.
LUNGS
ISORDIL 10MG should be used with caution in patients with impaired gas exchange due to lung disease. Consult your doctor before taking ISORDIL 10MG.
HEART DISEASE
ISORDIL 10MG is not recommended for use in patients who had a heart attack (myocardial infarction), circulatory failure and congestive heart failure. ISORDIL 10MG should be used with caution in heart conditions like hypertrophic obstructive cardiomyopathy (heart muscle becomes abnormally thick), constrictive pericarditis (sac-like covering of the heart (the pericardium) becomes thickened and scarred), cardiac tamponade (compression of the heart caused by fluid collecting in the sac surrounding the heart), low cardiac filling pressures, aortic/mitral valve stenosis, diseases associated with raised pressure in the head, or impaired gas exchange due to ischemic heart disease. Consult your doctor before taking ISORDIL 10MG.
OTHERS
ISORDIL 10MG is not recommended for use if you:
- suffer from anaemia (reduction in red blood cells which can make the skin pale and cause weakness or breathlessness)
- had a brain haemorrhage (bleeding)
- had a head injury (trauma)
- have a low blood volume (hypovolaemia)
- have very low blood pressure
Before taking ISORDIL 10MG inform your doctor if you:
- have glaucoma (increased pressure in the eye)
- have an underactive thyroid gland
- are undernourished as a result of poor diet
- are suffering from hypothermia
- suffer from very poor circulation
Use in pediatrics:
ISORDIL 10MG is not recommended for use in children. Consult child’s doctor for advice.
Use in geriatrics:
ISORDIL 10MG should be used with caution in elderly patients with kidney or liver disease. Consult your doctor before taking ISORDIL 10MG.
INTERACTIONS
A. Drug – Drug interactions:
Before taking ISORDIL 10MG, inform your doctor if you are taking any of the following medicines:
- betablockers (Ex. atenolol), calcium channel blockers (Ex. amlodipine), vasodilators (Ex. hydralazine), ACE inhibitors (Ex. enalapril) (used to manage high blood pressure)
- monoamine oxidase inhibitors such as phenelzine, selegiline and tricyclic antidepressants such as amitriptyline, amoxapine (used to manage depression)
- neuroleptics such as thioridazine, chlorpromazine (used to manage symptoms of schizophrenia)
- riociguat (used to manage pulmonary hypertension)
- phosphodiesterase inhibitors such as sildenafil, tadalafil, or vardenafil (used to manage male erectile dysfunction)
- ergotamine (used to manage migraine)
- sapropterin (used to lower phenylalanine levels in the blood)
Overdosage:
If you or anyone else accidentally takes too much of ISORDIL 10MG, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are extremely low blood pressure, nausea or dizziness.
SYNOPSIS
| Drug | :Â Â | Isosorbide dinitrate |
| Pharmacological Category | :Â Â | Nitrate Vasodilators |
| Therapeutic Indication | :  | Angina pectoris, Certain types of heart failure |
| Dosage Forms | :Â Â | Tablet |
MORE INFORMATION
- Keep ISORDIL 10MG out of reach of children
- Store at room temperature
FAQs ABOUT ISORDIL 10MG
Can I drink alcohol during management with ISORDIL 10MG?
You will be advised not to drink alcohol with ISORDIL 10MG. Drinking alcohol or taking medicines containing alcohol with this medicine may lower your blood pressure too much or affect you more than usual.
Can ISORDIL 10MG be given to children?
No, ISORDIL 10MG is not recommended for use in children. Your doctor will decide the correct dose or select a suitable alternative management for your child depending upon the specific disease condition
What if I forget to take a dose of ISORDIL 10MG?
If you forget to take a dose of ISORDIL 10MG, take it as soon as you remember. However, omit the missed dose if it is almost time for the next one. Do not double the dose to make up for the forgotten one
Can I take sildenafil while taking ISORDIL 10MG?
No, you should not take sildenafil along with this medicine. Both these medicines when used together it lowers the blood pressure and it can cause fainting or even a heart attack. Your doctor may prescribe alternate drug or change the interval between the drugs to prevent drug interactions in order to manage specific condition.
Is ISORDIL 10MG safe to use in patients with kidney disease?
ISORDIL 10MG should be used with caution in patients with severe kidney problems. Your doctor may monitor your kidney function test regularly to prevent any risk of damage to kidneys or unusual effects. Consult your doctor before taking ISORDIL 10MG.
REFERENCES
1. KD. Tripathi. Antianginal and Other Anti-ischaemic Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 544-545.
2. Thomas Michel and Brian B. Hoffman. Management of myocardial ischemia and hypertension. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 747-750 & 752.
3. Gerald G. Briggs and Roger K. Freeman. I. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 2099-2100.
4. Zheng Tan, Xiaoming Shang, Li li, Luobing tian, Yi ma, Yan peng and Lingxi gao. Clinical study of isosorbide mononitrate management for angina pectoris in coronary heart disease. NIH: National Library of Medicine, National Center for Biotechnology Information. February 2013. [Accessed on 1st August 2022]Â https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628368/
5. Stanley F.Malamed. Daniel L.Orr. Isosorbide Dinitrate. Medical Emergencies in the Dental Office (Seventh Edition). Science Direct. 2015. [Accessed on 1st August 2022]Â https://www.sciencedirect.com/topics/medicine-and-dentistry/isosorbide-dinitrate
6. Accord. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 1st August 2022]Â https://www.medicines.org.uk/emc/files/pil.5795.pdf
7. Meda Manufacturing GmbH. U.S. Food & Drug Administration. [Revised in January 2015] [Accessed on 1st August 2022]Â https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/012093s052lbl.pdf
USEFUL DIAGNOSTIC TESTS
- Electrocardiogram (ECG)
- Chest x-ray
- Chest CT
- Coronary CT angiography
- Cardiac MRI
- Coronary angiography
- Echocardiogram
| Weight | 17.5 g |
|---|
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