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Encorate Chrono 500mg Tablet 10’S

Name: Encorate Chrono 500mg Tablet 10'S
SKU: ut/med/68
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Original price was: ₹103.00.Current price is: ₹90.00.

*10 Tablet(s) in a Strip* Mkt: Sun Pharmaceutical Industries Ltd* Country of Origin: India* Delivery charges if applicable will be applied at checkout

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SKU: ut/med/68 Category: Medicine

Introduction About ENCORATE CHRONO 500MG TABLET

What is Encorate Chrono 500mg used for?

Encorate Chrono 500mg Tablet contains a combination of Valproic Acid and Sodium Valproate, known for their use in managing conditions related to irregular brain activity like Epilepsy and Bipolar disorder. This formulation is commonly advised by healthcare professionals for neurological conditions.

Encorate Chrono 500mg Tablet is not recommended for use in patients with liver problems or with a family history of liver problems, porphyria, blood coagulation or clotting disorders, pancreatic diseases, urea cycle disorder or Alpers-Huttenlocher syndrome (a rare disorder that affects brain, liver & muscles), etc.

Encorate Chrono 500mg Tablet should be used with caution in patients with kidney problems or lung diseases (such as chronic obstructive pulmonary disease) and diabetes. Encorate Chrono 500mg Tablet is also not recommended for use in pregnant and breastfeeding women. It should be used with caution in children (below 2 years of age). Consult your doctor before taking the medicine.

The common side effects of taking Encorate Chrono 500mg Tablet may include dizziness, headache, sleep disorders, clumsiness/unsteadiness, trembling of hands and arms and nervousness. Consult your doctor if any of the side effects worsen or persist.

Key Composition

Valproic acid
Sodium valproate

Uses Of ENCORATE CHRONO 500MG TABLET

Used to manage:

generalised, partial or other epilepsy
bipolar disorder

Benefits of ENCORATE CHRONO 500MG TABLET

1. Modified release formulation

Designed to release the active ingredients gradually over time, supporting more stable levels in the body and consistent performance throughout the day

Why modified release formulation matters?

Modified release tablets are designed to release the active ingredient slowly over a longer period. This supports more stable levels in the bloodstream and reduces sharp fluctuations that may occur with immediate-release forms
With prolonged effect, the tablet often requires fewer doses per day, typically once or twice. This simplifies medication schedules and improves consistency in usage, especially in long-term care
Simplified schedules are easier to follow, especially for individuals who need continuous neuro-support
Better adherence can lead to more predictable outcomes under medical supervision
Gradual release can lower the likelihood of peak-level side effects that sometimes occur when large doses are absorbed too quickly

2. Dual salt composition

Combines valproic acid and sodium valproate to support improved bioavailability and sustained delivery, commonly used in clinical settings for neurological balance support

3. Supports long-term use under monitoring

Often chosen in healthcare settings for extended use when accompanied by routine follow-up and monitoring protocols, enhancing usage confidence

How ENCORATE CHRONO 500MG TABLET Works

Encorate Chrono 500mg Tablet helps in managing epilepsy, where sodium valproate and valproic acid effectively increases the GABA (a neurotransmitter/chemical messenger) concentration in the central nervous system by reducing its degradation. It also blocks certain ion channels which reduce high-frequency neuronal activity in the brain, thereby reliving seizure activity.

How Encorate Chrono helps brain activity?

1. Supports neurochemical balance:

Encorate Chrono 500mg contains valproic acid and sodium valproate, which are known to influence neurotransmitter levels, especially gamma-aminobutyric acid (GABA). GABA plays a key role in calming overactive nerve signals in the brain

2. Regulates electrical activity in the brain

The formulation helps to stabilize irregular electrical impulses between brain cells. This is important in conditions where brain signal control is vital for maintaining overall neurological balance

3. Modified-release for continuous brain support

It is a modified-release design delivers the active ingredients slowly, providing consistent brain support throughout day and night, which may help to reduce sudden fluctuations in brain activity

4. Influences brain cell excitability

Valproate salts can help to reduce the over-excitability of neurons. This can promote a more balanced brain rhythm, especially in individuals who experience heightened neurological sensitivity.

How to use ENCORATE CHRONO 500MG TABLET

How to use Encorate Chrono 500mg Tablet

Encorate Chrono 500mg should only be used as advised by a registered medical professional. This modified-release tablet is designed to release the active ingredients gradually, supporting consistent neuro-support throughout the day.

Dosage Guidelines for Encorate Chrono

What is the correct dosage for Encorate Chrono 500mg?

The dosage is determined based on age, weight, and individual medical needs
Do not self-adjust the dose without consulting your doctor
Dosage may be modified over time based on clinical response and regular health monitoring

How many times a day should I take Encorate Chrono?

It is typically taken once or twice a day
Always take it at the same time daily for maximum effectiveness
Following a consistent routine supports stable levels in the bloodstream

Should Encorate be taken with food?

Yes, it is advised to take Encorate Chrono after meals. Taking it with food can help:

reduce the chance of stomach discomfort
improve absorption for some individuals

Encorate dosing instructions for adults and elderly

Adults: The dosage usually starts low and may be increased gradually as advised by the doctor
Elderly: Dosing may be adjusted carefully, especially in the patients with liver or kidney conditions. Regular monitoring of liver function and drug levels is often recommended

Safety Information

It is not recommended during pregnancy unless explicitly advised
May cause drowsiness, so it is best to avoid driving or operating machinery
Inform your doctor about liver conditions or history of allergic reactions
Regular liver function tests may be suggesteds

What if I forgot to take ENCORATE CHRONO 500MG TABLET

Take the missed dose as soon as you remember
If it is almost time for your next dose, skip the missed dose and resume your usual schedule
Do not double the dose to make up for a missed one
Use a pill reminder or daily tracker to help stay on schedule

Overdose

If you or anyone else accidentally takes too much of Encorate Chrono 500mg Tablet, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose may include nausea, vomiting, headache, blurred vision, dizziness, poor reflexes, confusion, memory loss, tiredness, muscle weakness, fits, loss of consciousness, behavioural changes and breathing difficulties such as fast breathing or shortness of breath or chest pain.

Side Effects Of ENCORATE CHRONO 500MG TABLET

What are the commonly reported side effects of Encorate Chrono 500mg?

Common

headache
sleep disorders
clumsiness or unsteadiness
trembling of hands and arms
nervousness
changing moods
blurred vision
ringing in ears
deafness
dizziness
flu
abdominal or stomach pain
heartburn
nausea and vomiting
diarrhoea
skin rash
hair loss or thinning of hair
back pain
change in menstrual periods
lack or loss of strength

Rare

unusual bleeding or bruising
abnormal dreams
anxiety
feeling sad
irritability
pain in joints
cough
constipation
dry eyes
spots before the eyes
ear infection
ear pain
runny nose
dental pain
bloating
muscle pains or stiffness
tiredness

When to report side effects to a healthcare provider?

signs of allergic reactions such as swelling of the face, lips, eyelids, throat and tongue, which may cause difficulty in breathing and swallowing
signs of liver problems characterized by nausea, vomiting, tiredness, sleepiness, weakness, stomach pain, yellowing of the skin or whites of the eye
signs of inflammation of the pancreas characterized by acute abdominal pain
chest pain, shortness of breath, hallucinations
suicidal thoughts
psychosis (mental disorder causing disconnection from reality)
toxic epidermal necrolysis (life-threatening skin disorder causing widespread skin pain, rashes, blisters, sores and crusting)
Steven-Johnson syndrome (a skin disorder characterized by painful rashes and blisters on the skin)
anaphylaxis (severe allergic reaction characterized by shortness of breath, fainting or fastened heartbeat)
erythema multiforme
polycystic ovarian syndrome (a disorder of ovaries characterized by irregular periods, hair growth on the skin, acne and weight gain)
brain diseases such as cerebral pseudo atrophy (loss of brain cells), encephalopathy (disease altering brain structure and functions) and coma (loss of consciousness)
signs of anaemia (decreased red blood cell count) as weakness, dizziness, pale skin and shortness of breath
abnormal behaviour such as changes in attention, concentration, mood, hallucinations or fits of more frequency and severity
signs of hypothyroidism (underactive thyroid gland) such as tiredness or weight gain
signs of pleural effusion (build-up of fluid between the tissues that line the lungs and the chest) such as breathing difficulty and pain
increase in the number and severity of convulsions
signs of systemic lupus erythematosus (autoimmune disorder) such as joint pain, fever, fatigue or rash
unsteadiness when walking due to parkinsonism (brain disorder), extrapyramidal disorder or ataxia (a disorder marked by impaired coordination)
uncontrollable and rapid movement of the eyes

Can Encorate Chrono impact mood or behaviour?

Some individuals may experience mood-related changes such as:

feeling unusually sad or irritable
restlessness or agitation
difficulty concentrating

Are there any long-term use considerations?

Liver function tests and blood count monitoring may be advised at regular intervals
Nutritional status (such as folate or carnitine levels) may be assessed during prolonged use
In some individuals, bone health assessments might be considered

How To Manage Side Effects

Dizziness Or Drowsiness

Stand up slowly from sitting or lying down
Avoid operating machinery or driving until the body adjusts
Maintain stable blood sugar levels by eating balanced meals regularly
Ensure adequate hydration

Headache

Stay well hydrated
Rest in a quiet, low-light area if symptoms arise
Use a cold compress on the forehead
Avoid triggers such as strong smells, screen overuse, or loud noises
Discuss with your doctor before taking any over-the-counter pain relievers

Nausea And Vomiting

Take Encorate Chrono after meals, not on an empty stomach
Eat small, frequent meals instead of large ones
Avoid greasy, spicy, or heavy foods
Sip on ginger tea or clear fluids (if permitted by your doctor)
Sit upright for at least 30 minutes after taking your dose

Encorate Chrono 500mg Tablet should be used with caution in elderly patients (aged above 68 years)

Other Warnings for ENCORATE CHRONO 500MG TABLET

Before taking Encorate Chrono 500mg Tablet, inform your doctor if you:

have diabetes
are scheduled for surgery such as dental surgery
have systemic lupus erythematosus
have a certain brain disease or any metabolic condition affecting your brain such as hypoglycaemic encephalopathy
have a deficiency condition such as carnitine palmitoyl transferase type II deficiency

Who should not take [GBNKEYWORD

Encorate Chrono 500mg Tablet is not recommended for use if you:

have porphyria
have blood coagulation or clotting disorders such as deep vein thrombosis, pulmonary embolism
have pancreatic diseases
have signs of urea cycle disorder such as loss of appetite, vomiting and lethargy that causes excessive ammonia builds up in the body
have a genetic disorder called Alpers-Huttenlocher syndrome

Diet and Lifestyle Advice

Recommended diet

Eat a Balanced Diet: Include fruits, vegetables, whole grains, lean protein, and healthy fats
Drink 6–8 glasses of water daily to help with digestion and drug metabolism
Calcium & Vitamin D: Include dairy, nuts, seeds, and green vegetables to support bone health during long-term use

Foods to Avoid:

Excess Sugar and Caffeine: Can affect mood and sleep
Grapefruit Juice: May interfere with liver enzymes

Drug – Drug interaction

1. Anticonvulsants (Anti-seizure Medications)

Phenytoin and Carbamazepine may lower the effectiveness of Encorate Chrono
Topiramate or Lamotrigine combined with Encorate Chrono may increase the risk of side effects such as tremors, dizziness, and drowsiness

2. Antidepressants

Selective serotonin reuptake inhibitors (SSRIs) like Fluoxetine or Paroxetine, and serotonin-norepinephrine reuptake inhibitors (SNRIs) like Venlafaxine, may increase the levels of valproic acid in the bloodstream, raising the risk of toxicity, including liver damage and sedation

3. Aspirin and Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

Aspirin and NSAIDs (such as Ibuprofen, Naproxen) can increase the blood levels of valproic acid, raising the risk of bleeding and gastrointestinal issues
They can also increase the risk of liver damage when used with Encorate Chrono

4. Blood thinners (Anticoagulants)

Warfarin and other blood thinners can have their effects enhanced when taken with Encorate Chrono, leading to a higher risk of bleeding

5. Antibiotics (e.g., Rifampin, Erythromycin)

Rifampin can lower the levels of Encorate Chrono, making it less effective
Erythromycin can increase the levels of valproic acid, which could lead to toxicity

6. Antipsychotics and Sedatives

Antipsychotic medications such as Olanzapine, Risperidone, or Quetiapine, and sedatives like Benzodiazepines may interact with Encorate Chrono, leading to enhanced sedative effects, including drowsiness, confusion, or respiratory depression

7. Valproic acid and other drugs metabolized by the liver

Encorate Chrono can affect the liver enzymes, which might alter the metabolism of other drugs, including statins (cholesterol medications), antihypertensives, and diabetes medications

8. Oral contraceptives

Encorate Chrono may lower the effectiveness of certain oral contraceptives, increasing the risk of unintended pregnancy

9. Other interactions

Cimetidine (for acid reflux) and Carbapenem antibiotics can also affect the metabolism of valproic acid, leading to either reduced efficacy or increased toxicity

Synopsis

Drug	:	Sodium valproate, Valproic acid
Pharmacological Category	:	Anticonvulsants/Antiepileptics
Therapeutic Indication	:	Epilepsy, Bipolar disorder
Dosage Forms	:	Tablet

More Information

Encorate Chrono vs. Similar Products

Feature	Encorate Chrono 500mg	Depakote (Immediate-Release)
Formulation Type	Modified-release (MR)	Immediate-release (IR)
Dosing Frequency	Once or twice daily	Multiple doses per day (usually 2-3)
Active Ingredient	Valproic acid (sodium valproate)	Valproic acid (sodium valproate)
Mechanism of action	Increases GABA activity and stabilizes sodium channels	Increases GABA activity and stabilizes sodium channels
Use in Seizure Control	Yes	Yes
Use in Mood Disorders	Yes (Bipolar disorder)	Yes (Bipolar disorder)
Common Side Effects	Nausea, dizziness, weight gain, tremors	Nausea, dizziness, tremors, GI distress
Side Effect Frequency	Generally lower due to MR formulation	Higher due to rapid absorption and peaks
Liver Function Monitoring	Yes (routine checks recommended)	Yes (routine checks recommended)
Pregnancy Category	Category D (Risk of harm to fetus)	Category D (Risk of harm to fetus)
Breastfeeding Considerations	Excreted in milk in low amounts, monitor infant	Excreted in milk, monitor infant
Drug Interactions	Numerous (especially with other anticonvulsants and antidepressants)	Numerous (especially with other anticonvulsants)
Patient Adherence	Easier adherence due to once-daily dosing	More frequent dosing may impact adherence
Long-Term Use Monitoring	Liver function, growth, cognitive health	Liver function, GI health, cognitive health

Understanding the Brain chemistry behind Encorate Chrono 500mg

Encorate Chrono 500mg contains valproate sodium, an active compound that primarily affects the central nervous system (CNS). It plays a key role in managing conditions such as epilepsy and mood disorders by influencing the chemical signals in the brain. Here how it works:

1. Increase in GABA Activity

Encorate Chrono is believed to increase the levels of GABA (gamma-aminobutyric acid), a neurotransmitter in the brain that helps calm neuronal activity. GABA acts as an inhibitory neurotransmitter, meaning it reduces the excitability of neurons. This calming effect helps to prevent excessive brain activity which could otherwise lead to seizures or mood swings

2. Stabilizing Electrical Activity in the Brain

The brain functions based on electrical signals between neurons. In conditions like epilepsy, abnormal and excessive electrical activity leads to seizures. Encorate Chrono helps stabilize this electrical activity, reducing the frequency and severity of seizures by suppressing abnormal nerve firing

3. Inhibition of Enzymes

Valproate also inhibits certain enzymes that are involved in the breakdown of GABA in the brain. This manages GABA from being rapidly broken down, thus allowing it to remain active for longer periods. This action enhances the inhibitory effect on nerve cells, contributing to seizure control.

4. Effect on Sodium channels

Encorate Chrono may also modulate sodium channels, which are responsible for conducting electrical signals between neurons. By stabilizing these channels, Encorate helps to manage abnormal electrical discharges, which are often the cause of seizures and certain mood disorders.

5. Mood Regulation

For conditions such as bipolar disorder, the stabilizing effect on the brain’s neurotransmitters helps balance mood fluctuations. By modulating GABA and influencing other neurotransmitters, Encorate Chrono can help regulate mood swings in affected individuals.

What makes Encorate Chrono Unique?

The modified-release formulation of Encorate Chrono is designed to release the active ingredients gradually. This offers:

Consistent therapeutic levels of valproate throughout the day
Reduced risk of side effects related to peaks and troughs in drug concentration
Improved patient adherence due to fewer daily doses

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